Latest Research HBOT and PEMF

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29 YEAR OLD FEMALE WITH STAGE 4 BREAST CANCER RESPONDS SUCCESSFULLY TO COMBINATION THERAPY INVOLVING HYPERBARIC OXYGEN THERAPY

September 14, 2022

29 YEAR OLD FEMALE WITH STAGE 4 BREAST CANCER RESPONDS SUCCESSFULLY TO COMBINATION THERAPY

Triple-negative breast cancer (TNBC) is considered to be one of the more aggressive types of breast cancer, and is typically treated with chemotherapy. Cancers like these that are able to rapidly grow and spread are a major concern and need to be treated with an equally aggressive solution. This is why we are seeing more research and clinical trials utilizing combination therapies in order to help intensify the cytotoxic effects of chemotherapy in an aggressive measure to counteract these highly metastatic cancers. This report followed a 29 year old female that was put on an aggressive combination of chemotherapy, hyperthermia therapy, hyperbaric oxygen therapy, and a ketogenic diet. The results were remarkable and “presents evidence of a complete clinical, radiological, and pathological response following a six-month treatment period using this novel combination therapy in a patient with stage IV TNBC” <view study> Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer - PubMed (nih.gov)

A 60-Hz sinusoidal magnetic field induces apoptosis of prostate cancer cells through reactive oxygen species

September 22, 2022

A 60-Hz sinusoidal magnetic field induces apoptosis of prostate cancer cells through reactive oxygen species

This study explores the effects of power frequency magnetic fields (MF) on cell growth in prostate cancer, DU145, PC3, and LNCaP cells were examined in vitro. The cells were exposed to various intensities and durations of 60-Hz sinusoidal MF in combination with various serum concentrations in the media. To analyze MF effects on cell growth, cell counting, trypan blue exclusion assay, Western blot analysis, flow cytometry, enzyme-linked immunosorbent assay (ELISA), semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), fluorescence microscopy, and spectrofluorometry were used. MF exposure induced significant cell growth inhibition and apoptosis in an intensity- and time-dependent manner, in which cell cycle arrest, cleaved Caspase-3, and reactive oxygen species (ROS) increased. Pretreatment with a Caspase-3 inhibitor or antioxidant, N-acetyl-L-cysteine (NAC), significantly attenuated MF-induced cell growth inhibition and cell death. Media replacement experiments failed to show any notable change in the MF effects. Conclusions. These results demonstrate 60-Hz sinusoidal MF-activated cell growth inhibition of prostate cancer in vitro. Apoptosis together with cell cycle arrest were the dominant causes of the MF-elicited cell growth inhibition, mediated by MF-induced ROS. These results suggest that a possibility of using 60-Hz MF in radiation therapy of prostate cancer could usefully be investigated. Eui Kwan Koh, Byung-Kyu Ryu, Dong-Young Jeong, Iel-Soo Bang, Myung Hee Nam & Kwon-Seok Chae (2008) A 60-Hz sinusoidal magnetic field induces apoptosis of prostate cancer cells through reactive oxygen species, International Journal of Radiation Biology, 84:11, 945-955, DOI: 10.1080/09553000802460206 Source

A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field in the treatment of musculoskeletal chronic pain

September 22, 2022

A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field

Exposure to a specific pulsed electromagnetic field (PEMF) has been shown to produce analgesic (antinociceptive) effects in many organisms. In a randomized, double-blind, sham-controlled clinical trial, patients with either chronic generalized pain from fibromyalgia (FM) or chronic localized musculoskeletal or inflammatory pain were exposed to a PEMF (400 microT) through a portable device fitted to their head during twice-daily 40 min treatments over seven days. The effect of this PEMF on pain reduction was recorded using a visual analogue scale. A differential effect of PEMF over sham treatment was noticed in patients with FM, which approached statistical significance (P=0.06) despite low numbers (n=17); this effect was not evident in those without FM (P=0.93; n=15).

PEMF may be a novel, safe and effective therapeutic tool for use in at least certain subsets of patients with chronic, nonmalignant pain. Clearly, however, a larger randomized, double-blind clinical trial with just FM patients is warranted.

Thomas AW, Graham K, Prato FS, McKay J, Forster PM, Moulin DE, Chari S. A randomized, double-blind, placebo-controlled clinical trial using a low-frequency magnetic field in the treatment of musculoskeletal chronic pain. Pain Res Manag. 2007 Winter;12(4):249-58. doi: 10.1155/2007/626072. PMID: 18080043; PMCID: PMC2670735.

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A REVIEW ON THE NEUROPROTECTIVE EFFECTS OF HYPERBARIC OXYGEN THERAPY

September 14, 2022

A REVIEW ON THE NEUROPROTECTIVE EFFECTS OF HYPERBARIC OXYGEN THERAPY

Hyperbaric oxygen therapy has clinically been reported to have many benefits within the body, particularly for a wide range of neurological disorders, including spinal cord injuries , brain injuries, neurodegenerative diseases (ie,Parkinson's Alzheimer's), neurodevelopment disorders (ie, Cerebral Palsy, Autism), and peripheral nerve injuries. The beneficial effects can largely be attributed to the protective anti-oxidative and anti-inflammatory effects that this procedure promotes. “The evidence presented in this review indicates the potential of HBOT in treatment and prevention of a variety of injuries to the nervous system” <view study> A review on the neuroprotective effects of hyperbaric oxygen therapy Ahmadi F, Khalatbary AR - Med Gas Res

A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment

September 22, 2022

A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment

Current popular cancer treatment options, include tumor surgery, chemotherapy, and hormonal treatment. These treatments are often associated with some inherent limitations. For instances, tumor surgery is not effective in mitigating metastases; the anticancer drugs used for chemotherapy can quickly spread throughout the body and is ineffective in killing metastatic cancer cells. Therefore, several drug delivery systems (DDS) have been developed to target tumor cells, and release active biomolecule at specific site to eliminate the side effects of anticancer drugs. However, common challenges of DDS used for cancer treatment, include poor site-specific accumulation, difficulties in entering the tumor microenvironment, poor metastases and treatment efficiency. In this context, non-invasive cancer treatment approaches, with or without DDS, involving the use of light, heat, magnetic field, electrical field and ultrasound appears to be very attractive. These approaches can potentially improve treatment efficiency, reduce recovery time, eliminate infections and scar formation. In this review we focus on the effects of magnetic fields and ultrasound on cancer cells and their application for cancer treatment in the presence of drugs or DDS. Somoshree Sengupta, Vamsi K. Balla, A review on the use of magnetic fields and ultrasound for non-invasive cancer treatment, Journal of Advanced Research, Volume 14, 2018, Pages 97-111, ISSN 2090-1232, https://doi.org/10.1016/j.jare.2018.06.003. (http://www.sciencedirect.com/science/article/pii/S2090123218300778) Source

ALZHEIMER’S DISEASE — RESEARCHERS FIND HYPERBARIC OXYGEN REDUCES AMYLOID PLAQUES AND CAUSES LARGE GAINS IN BLOOD FLOW TO THE BRAIN

September 14, 2022

ALZHEIMER’S DISEASE — RESEARCHERS FIND HBO REDUCES AMYLOID PLAQUES AND CAUSES LARGE GAINS

This exciting new study shows that Hyperbaric Oxygen therapy (HBOT) may REVERSE dementia development by preventing the deposit of new amyloid plaques on the brain cells and even leading to the removal of existing ones! The 2 most common types of dementia are vascular dementia and Alzheimer’s disease (AD). It is now believed that hyperbaric oxygen therapy can effectively help to halt both of these devastating conditions, while also being able to help reverse the cognitive decline seen in the aging process. The production of amyloid plaques are a hallmark of AD, consisting of hard, insoluble accumulations of beta amyloid proteins that clump together between the nerve cells and block their communication. Compounding this, is a reduction in oxygen (hypoxia) and reduction in blood flow to these regions inside the brain. Since the pathophysiology includes both the build up of amyloid plaques and a reduction in cerebral blood flow (CBF), the researchers designed this study to deploy a typical course of HBOT and then observe any changes in both amyloid plaque and CBF, while also documenting any clinical improvements. They did this by presenting a 2-fold study, the first being an animal study which was then followed up with a small human study. Both showed extremely promising results and confirmed previous studies for HBOT’s potential role in treating dementia and memory loss. Initial Animal Study: Mice were exposed to 20 HBOT sessions (2.0 ATA, 60 min) causing a significant:
  • Reduction in amyloid burden (by reducing the volume of pre-existing plaques and attenuating the formation of new ones).
  • Improvement in vascular parameters
  • Improvement in behavior and performance of cognitive-based tasks.
Human follow-up study: Six elderly patients with significant memory loss were treated with 60 HBOT sessions (2.0 ATA, 90 min) and both CBF and cognitive function were evaluated and the results were as follows:
  • Cerbral Blood Flow — Following HBOT, there were significant CBF increases in several brain areas, including 8 Brodmann areas.
  • Cognitive function — Cognitive assessment revealed a significant increase in the global cognitive score, where memoryattention and information processing speed domain scores showed most benefits. The improvements in these scores correlated with improved short and working memory.
This study, along with previous studies by these authors, demonstrates that hyperbaric oxygen therapy can be deployed at any stage of the dementia process, from early on with mild cognitive impairment, to advanced stages seen in Alzheimer's. disease. <view study> <view media Exclusive: Alzheimer’s could be ‘halted’ using oxygen therapy> **Please note we offer 1.3ATA which is proven to be just as beneficial as 2.0ATA <view study The Debate is over — Low pressure hyperbaric oxygen therapy proves its effectiveness – @Hyperbaric Experts>

Alzheimer’s Disease: Improvement of Visual Memory and Visuoconstructive Performance by Treatment with Picotesla Range Magnetic Fields

September 22, 2022

Alzheimer’s Disease: Improvement of Visual Memory and Visuoconstructive Performance

Impairments in visual memory and visuoconstructive functions commonly occur in patients with Alzheimer’s disease (AD). Recently, I reported that external application of electromagnetic fields (EMF) of extremely low intensity (in the picotesla range) and of low frequency (in the range of 5Hz-8Hz) improved visual memory and visuoperceptive functions in patients with Parkinson’s disease. Since a subgroup of Parkinsonian patients, specifically those with dementia, have coexisting pathological and clinical features of AD, I investigated in two AD patients the effects of these extremely weak EMF on visual memory and visuoconstructive performance. The Rey-Osterrieth Complex Figure Test as well as sequential drawings from memory of a house, a bicycle, and a man were employed to evaluate the effects of EMF on visual memory and visuoconstructive functions, respectively. In both patients treatment with EMF resulted in a dramatic improvement in visual memory and enhancement of visuoconstructive performance which was associated clinically with improvement in other cognitive functions such as short term memory, calculations, spatial orientation, judgement and reasoning as well as level of energy, social interactions, and mood. The report demonstrates, for the first time, that specific cognitive symptoms of AD are improved by treatment with EMF of a specific intensity and frequency. The rapid improvement in cognitive functions in response to EMF suggests that some of the mental deficits of AD are reversible being caused by a functional (i.e., synaptic transmission) rather than a structural (i.e., neuritic plaques) disruption of neuronal communication in the central nervous system.

Reuven Sandyk (1994) Alzheimer’s Disease: Improvement of Visual Memory and Visuoconstructive Performance by Treatment with Picotesla Range Magnetic Fields, International Journal of Neuroscience, 76:3-4, 185-225, DOI: 10.3109/00207459408986003

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Cystatin C Is a Crucial Endogenous Protective Determinant Against Stroke

September 22, 2022

Cystatin C Is a Crucial Endogenous Protective Determinant Against Stroke

Endogenous neuroprotection can be induced by ischemic and nonischemic preconditioning. However, not all subjects that undergo preconditioning exhibit similar favorable outcome. This study is to explore the molecules responsible for this phenomenon and find new therapeutic targets for stroke. Adult male Sprague–Dawley rats were subjected to transient middle cerebral artery occlusion. High-throughput proteomic technique, isobaric tag for relative and absolute quantification, was used to screen differentially expressed proteins in the rats that developed ischemic tolerance from hyperbaric oxygen (HBO) preconditioning. The proteomic results were verified by Western blot and ELISA. Then, short interfering RNA and gene knockout rats were used to further determine the pivotal role of candidate proteins in HBO preconditioning–induced endogenous neuroprotection. Finally, lysosomal permeability was tested to elaborate the mechanism underlying this intrinsic neuroprotective effect. Nine proteins differentially expressed in the serum of rats, which acquired benefits from HBO preconditioning, were screened and identified. Western blot and ELISA revealed that cystatin C (CysC) and mannose-binding lectin protein C were uniquely changed in rats with smaller infarction after HBO preconditioning and cerebral ischemia. Knockdown and knockout of CysC abolished HBO-induced neuroprotection. Moreover, HBO-induced endogenous CysC elevation preserved lysosomal membrane integrity after stroke in wild-type rats but not in CysC siRNA infusion or CysC−/− rats. Most importantly, exogenous CysC also induced neuroprotection against ischemic/reperfusion injury. Conclusion. CysC is a crucial determinant contributing to endogenous neuroprotection. It is also a novel candidate for stroke treatment through maintaining lysosomal membrane integrity. Zongping Fang, MD, PhD, Jiao Deng, MD, PhD, Zhixin Wu, MD, Beibei Dong, MD, Shiquan Wang, MD, Xiaodan Chen, MD, Huang Nie, MD, PhD, Hailong Dong, MD, PhD, and Lize Xiong, MD, PhD, Stroke, Volume 48, Issue 2, February 2017, Pages 436-444. https://doi.org/10.1161/STROKEAHA.116.014975.

Effect of Electromagnetic Field and Allicin as Natural Extract on Hepatocellular Carcinoma (HepG2)

September 22, 2022

Effect of Electromagnetic Field and Allicin as Natural Extract on Hepatocellular Carcinoma (HepG2)

Cancer is one of the major public burdens worldwide. It is a multicellular disease that can arise from all cell type. In the recent decades, the number of cancer related showed a clear elevation, in turn creating huge health and economic problems. Non-ionizing Electromagnetic Fields (EMF), from extremely-low frequency to radiofrequency, have been shown to cause biological effects even at low intensity. Some of these effects may be applied for medical treatments. Exposure to PEMFs in the 0-300Hz range is a therapeutic tool extensively used for the treatment of several pathologies. Allicin is an organic sulfur compound from the bulbs of Allium sativum, which is also present in onions and other Allianceae plants. Allicin has strong antibacterial and anti-inflammatory effects, and may inhibit the growth of or kill various bacteria, fungi and viruses. A previous epidemiological study demonstrated the antitumor activity of allicin has been shown to directly kill tumor cells, inhibit tumor cell proliferation and induce apoptosis. Aim of Study: This study investigates the anticancer activity of EMF, allicin and combination between them in the treatment of Hepatocellular carcinoma (HepG2). Material and Methods: Human Hepatocellular carcinoma (HepG2) ATCC®HB-8065 cell lines was supplied from Re-search and Development Sector, The Holding Company for production of Vaccines, Sera and Drugs (VACSERA), Cairo, Egypt. Electromagnetic fields exposure, Allicin 95% was kindly supplied from the national organization for drug control and research (NODCAR). Cytotoxicity, Flowcytometry and Quantitative Real-Time RT PCR (q RT-PCR) anticancer activity of EMF, EMF-Allicin and Allicin compared to cisplatin was investigated through the expression of BAX, P53 and BCL2 genes using real-time RT-PCR. Results: Data revealed that cytotoxicity was concentration and cell type-dependent, as lower concentration enhanced the higher viability profile, the concentration of allicin of 2µg/ml, cell viability reached 100% on both of vero cells and HepG2 cells. The inhibitory concentration (IC50) for Vero cells, and HepG2 was 9.47µg/ml and 69.4µg/m respectively. The treatment with both EMF-Allicin is more efficient than treatment with EMF or Allicin separately. In the present study there was a significant up regulation of both pro-apoptotic genes (Bax- P53) accompanied by significant down regulation of anti-apoptotic gene (BCL-2) relative to exposure to EMF + Allicin. Conclusion: EMF can be used in therapy as its non-invasive technique used for the treatment of several pathologies and cancer. Combination between EMF + Allicin can induce apoptosis and inhibition of proliferation in HepG2 cell line. Ph.D., MAHA & AZIZ, M.Sc. (2020). Effect of Electromagnetic Field and Allicin as Natural Extract on Hepatocellular Carcinoma (HepG2). The Medical Journal of Cairo University. 88. 815-825. 10.21608/mjcu.2020.104890. Source

Effect of pulsed electromagnetic field on nonspecific low back pain patients: a randomized controlled trial

September 22, 2022

Effect of pulsed electromagnetic field on nonspecific low back pain patients: a randomized controlled trial

Further research on pulsed electromagnetic field (PEMF) effects on the different conditions of low back pain was warranted due to lack of studies in this area. To investigate the effects of pulsed electromagnetic field therapy with 50 Hz frequency, with low intensity of 20 Gauss compared to conventional non-invasive treatment modalities in patients with chronic non-specific low back pain. This study conclused that adding pulsed electromagnetic field to Conventional physical therapy Protocol yields superior clinical improvement in pain, functional disability, and lumbar ROM in patients with non-specific low back pain than Conventional physical therapy alone. Elshiwi AM, Hamada HA, Mosaad D, Ragab IMA, Koura GM, Alrawaili SM. Effect of pulsed electromagnetic field on nonspecific low back pain patients: a randomized controlled trial. Braz J Phys Ther. 2019 May-Jun;23(3):244-249. doi: 10.1016/j.bjpt.2018.08.004. Epub 2018 Aug 21. PMID: 30177406; PMCID: PMC6531640. Source

Effectiveness of magnetotherapy in optic nerve atrophy: a preliminary study

September 22, 2022

Effectiveness of magnetotherapy in optic nerve atrophy: a preliminary study

Magnetotherapy effects on visual functions (vision acuity and field), on retinal bioelectric activity, on conductive vision system, and on intraocular circulation were studied in 88 patients (160 eyes) with optic nerve atrophy. A Soviet Polyus-1 low-frequency magnetotherapy apparatus was employed with magnetic induction of about 10 mT, exposure 7-10 min, 10-15 sessions per course. Vision acuity of patients with its low (below 0.04 diopters) values improved in 50 percent of cases. The number of patients with vision acuity of 0.2 diopters has increased from 46 before treatment to 75. Magnetotherapy improved ocular hemodynamics in patients with optic nerve atrophy, it reduced the time of stimulation conduction along the vision routes and stimulated the retinal ganglia cells. The maximal effect was achieved after 10 magnetotherapy sessions. A repeated course carried out in 6-8 months promoted a stabilization of the process. Zobina LV, Orlovskaia LS, Sokov SL, Sabaeva GF, Kondé LA, Iakovlev AA. Effektivnost’ magnitoterapii pri atrofii zritel’nogo nerva. Predvaritel’noe issledovanie [Effectiveness of magnetotherapy in optic nerve atrophy. A preliminary study]. Vestn Oftalmol. 1990 Sep-Oct;106(5):54-7. Russian. PMID: 2264232. Source

Effects of extreme low frequency pulsed electromagnetic field added to kinesitherapy procedure on quality of life in patients with end stage renal disease on dialysis

September 22, 2022

Effects of extreme low frequency pemf added to kinesitherapy procedure on quality of life in patients

Extreme Low Frequency Pulsed Electromagnetic Magnetic Field (ELF-PEMF) has a wide range of therapeutic applications which has expanded during the last decades. ELF-PEMF as non-invasive, long term safe method of physical therapy can influence a variety of aspects in chronic diseases including quality of life. Patients with chronic kidney disease (CKD) especially with end stage renal disease (ESRD) treated by dialysis have lower health-related quality of life and changed normal way of living because of ESRD-related co morbid illnesses, associated conditions and complex dyalisis procedures.

The objective of this study was to assess the effectiveness of long-term ELF-PEMF in concordance with exercising on the quality of life in ESRD patients on dialysis. Methods. In study group treatment with ELF-PEMF significantly improved FACIT Fatigue v4 scale score as well as physical health, physical functioning, bodily pain and energy/fatigue domains of SF=36v2 scale. There were no effects on mental health domain, limitations due to physical health problems, limitations due to personal or emotional problems, emotional well-being, social functioning, and general health perceptions. In the control group, no beneficial effects on FACIT Fatigue v4 scale and SF36v2 scale item were noticed. Conclusion. ELF-PEMF could be an additional and safe strategy for improving the quality of life in patients with ESRD on dialysis.

In conclusion, treatment with ELF-PEMF significantly improves physical health, physical functioning, bodily pain and energy/fatigue. Importantly, there have been no reports of side-effects of ELF-PEMF which had a clearly superior safety profile. Our results left enough space for improvement to significant values in forthcoming, larger studies. The time to onset and subsequent longevity of ELF-PEMF effects should be considered in future study design to achieve an accurate measurement. A clearer definition of the mechanisms might also help in choosing patients who are more likely to benefit from such a treatment.

Rakocevic-Hrnjak, Aleksandra & Vuksanovic, Miljanka & Dimkovic, Nada & Djurovic, Aleksandar & Petronijevic, Natasa & Petronijevic, Milan. (2017). Effects of extreme low frequency pulsed electromagnetic field added to kinesitherapy procedure on quality of life in patients with end stage renal disease on dialysis. Vojnosanitetski pregled. 75. 7-7. 10.2298/VSP160620007R.

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Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients exposed to microvascular endothelial cells conditioned medium

September 22, 2022

Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients

Intervertebral disc (IVD) degeneration with chronic low back pain is associated with neo-vascularisation into the deeper IVD regions. During this process, endothelial cells (ECs), which are primarily responsible for angiogenesis, interact with the adjacent annulus fibrosus (AF) cells, which are the first line of defence against the invasion of vascular structures into deeper IVD regions. However, the accumulation of inflammatory and catabolic enzymes that results from this interaction promotes matrix degradation and an inflammatory response. Thus, regulating the production of these mediators and catabolic enzymes could ameliorate IVD degeneration. Photobiomodulation (PBM) therapy is a non-invasive stimulation known to have biologically beneficial effects on wound healing, tissue repair, and inflammation. Here, we examined the effects of PBM, administered at various wavelengths (645, 525, and 465 nm) and doses (16, 32, and 64 J/cm2), on EC-stimulated human AF cells. Our results show that PBM selectively inhibited the EC-mediated production of inflammatory mediators, catabolic enzymes, and neurotrophins by human AF cells in a dose- and wavelength-dependent manner. These results suggest that PBM could be a superior and advanced treatment strategy for IVD degeneration.

Hwang MH, Lee JW, Son HG, Kim J, Choi H. Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients exposed to microvascular endothelial cells conditioned medium. Sci Rep. 2020 Jun 15;10(1):9655. doi: 10.1038/s41598-020-66689-0. PMID: 32541845; PMCID: PMC7296027.

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Effects of Pulsed Electromagnetic Field Therapy on Pain, Stiffness and Physical Function in Patients with Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

September 22, 2022

Effects of PEMF Therapy on Pain, Stiffness and Physical Function in Patients with Knee Osteoarthritis

Effects of Knee osteoarthritis is currently one of the most common joint diseases worldwide. Pulsed electromagnetic field therapy has become popular among patients with knee osteoarthritis in recent years. However, the efficacy of this therapy on joint pain, joint stiffness and physical function is regarded as controversial in published clinical trials and systematic reviews. Several new randomized controlled studies on this subject have been published recently. The aim of this systematic review and metaanalysis is therefore to assess the efficacy of classical pulsed electromagnetic field therapy on patients with knee osteoarthritis, according to the methodology set out in the Cochrane Handbook for Systematic Reviews of Interventions. The results show that, despite showing no advantage in the management of pain and stiffness, pulsed electromagnetic field therapy is beneficial for improving clinical symptoms, such as physical function of the knee joint; thus it may be recommended as a supplementary therapy option for knee osteoarthritis. This review provides some evidence to help resolve current controversies about the efficacy of pulsed electromagnetic field therapy for knee osteoarthritis.

Li CHEN, MD, PhD, Xin DUAN, MD, PhD, Fei XING, MD, Guoming LIU, MD, Min GONG, MD, Lang LI, MD, Ran CHEN, MD and Zhou XIANG, MD, PhD From the Department of Orthopedics and National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan, China. J Rehabil Med 2019; 51: 821–827

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Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

September 22, 2022

Effects of PEMF on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats

Levels of antioxidants in individuals with diabetes increase initially as a response to increases in reactive oxygen species (ROS) and later decrease due to reactions between free radicals and antioxidants. As the disease progresses, antioxidant mechanisms can be damaged in parallel to tissue damage, reducing antioxidant levels. Generalization should be avoided, however, due to increases in vitamin E levels due to hyperlipidemia and increases in ferritin levels due to of inflammation. The effects of antioxidants in organs are dependent on tissue physiology. Enzymatic antioxidants are more effective within cells, whereas non-enzymatic antioxidants have a greater effect in the extracellular environment.

In conclusion, this study investigated the antioxidant effects of PEMF in a rat model of diabetes. PEMF altered the levels of MDA, NO, MPO, SOD, and GSH, suggesting that it regulates diabetes-associated damage. PEMF exerts these effects by reducing oxidative stress and increasing antioxidant levels. These findings suggest that PEMF may become a widespread non-invasive treatment option for diabetes and its complications.

Gözen H, Demirel C, Akan M, Tarakçıoğlu M. Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats. Eur J Ther 2017; 23: 152-8.

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Evaluation of Radiofrequency Devices in Aesthetic Medicine: A Preliminary Report

September 21, 2022

Evaluation of Radiofrequency Devices in Aesthetic Medicine: A Preliminary Report

In recent years, there has been an explosion of non-invasive devices to promote wrinkle, cellulite and fat reduction in patients who do not want invasive surgery. According to the American Society of Plastic Surgery in 2015 the annual number of minimal or non-invasive procedures has nearly tripled since 2000. In 2013, the International Society of Aesthetic Plastic Surgery reported over 1.6 million liposuction procedures were performed globally. During that time, nearly 95,000 non-surgical fat reduction procedures and 294,000 non-surgical skin tightening procedures were done in the USA alone. Many studies are used to promote the sales of non-invasive devices, yet objective peer review studies are scarce. One of the more popular and growing uses of technology in aesthetic medicine is that of Radiofrequency (RF). The purpose of this study is to review the evolution of more commonly used radio frequency (RF) based devices. It also aims to generate a professional opinion on their use and efficacy. There are many benefits and challenges associated with the use of RF in aesthetic medicine. Hand piece size alongside treatment area, permeation of RF into the skin and consistency of results are all challenges. It seems evident that challenges associated with RF arching and temperature control have improved significantly in recent generations of technology. It is clear that the use of Radiofrequency in medicine for cosmetic purposes continues to evolve and is likely to stay. Starting with the introduction of mono-polar RF now to multi-polar and even micro needling with RF aesthetic medicine has progressed through a technological evolution. Over the last 15 years there have been five separate generations RF with the most recent developments occurring in 2016. All of these studies show improvement in wrinkle and fat reduction. However, long term data has not been established. Further studies are needed in that area. Thomas Narsete, Daniel S Narsete (2017) Evaluation of Radiofrequency Devices in Aesthetic Medicine: A Preliminary Report. J Dermatol & Ther 1:102. Source

Extremely low frequency electromagnetic field and wound healing: Implication of cytokines as biological mediators

September 22, 2022

Extremely low frequency electromagnetic field and wound healing: Implication of cytokines as biological mediators

Wound healing is a highly coordinated and complex process involving various cell types, chemical mediators and the surrounding extracellular matrix, resulting in a tightly orchestrated re-establishment of tissue integrity by specific cytokines. It consists of various dynamic processes including a series of overlapping phases: inflammation, proliferation, re-epithelialization and remodeling. One of the underlying mechanisms responsible for the disturbances in wound healing is an out-of-control inflammatory response that can cause pathological consequences, such as hypertrophic scars, keloids or chronic wounds and ulcers. Recently, several reports have evaluated the effects of extremely low frequency electromagnetic fields (EMFs) on tissue repair. In particular, the data analysis supports an anti-inflammatory effect of EMFs by the modulation of cytokine profiles that drive the transition from a chronic pro-inflammatory state to an anti-inflammatory state of the healing process. In this review, we focus on the effect of EMFs on skin wound healing showing emerging details of the anti-inflammatory effects of EMFs, with a view to cytokines as candidate biomarkers. Molecular clarification of the mechanisms involved in the modulation of inflammatory factors following exposure to EMFs will provide a better understanding of the cellular responses induced by EMFs and a potential, additional treatment in non-responding, chronic wounds. Pesce, Mirko & Patruno, Antonia & Speranza, Lorenza & Reale, Marcella. (2013). Extremely low frequency electromagnetic field and wound healing: Implication of cytokines as biological mediators. European cytokine network. 24. 1-10. 10.1684/ecn.2013.0332. Source

FUNCTIONAL MRI IMAGING CONFIRMS LONG-TERM STROKE PATIENTS CAN IMPROVE WITH HYPERBARIC OXYGEN THERAPY, EVEN 15 YEARS AFTER THE STROKE

September 14, 2022

LOW PRESSURE HYPERBARICS IMPROVES CEREBRAL BLOOD FLOW IN FIREFIGHTERS WITH MILD TBI AND EMOTIONAL DISTRESS

Management of chronic strokes remains a challenge within our current medical system, yet the intervention of hyperbaric oxygen therapy has consistently been shown to improve stroke recovery, even years after the brain insult.

This study followed 4 patients (from 14 months to 15 years post stroke) who were given a typical 8 week hyperbaric protocol consisting of 40 individual sessions (at an effective dosage of 1.8 ATA) and evaluated the outcome measures through functional MRI imaging (fMRI). Note, fMRI is a non invasive, robust and reliable technique to assess and monitor neuronal functional change.

The results were very impressive and should give encouragement for this protocol to be more widely used within the stroke recovery community. Here is a summary of all 4 patients along with the details regarding their recovery:

60 year old male (14 month old stroke) with severe, non-fluent aphasia, associated with retained comprehension, dyslexia and dysgraphia, a right upper limb spastic paralysis and a right lower limb paresis, and post-stroke depression.

Aphasia and the ability to speak improved noticeably, helping to regain some social life. Accordingly, the negative attitude was replaced by positivity, good mood and interest. Right lower limb paresis improved with better gait and stance. However, the right hand paralysis did not improve, except for a decrease in spasticity

68 year old male (5 year old stroke) with moderate signs of dysarthria (he sounded clumsy in reading aloud short passages), an unsteady, wide-base gait and dysphagia

A marked clinical improvement in the language fluency, such that he was able to read aloud a written text, without a hitch. Ataxia and dysphagia improved as well

48 year old male (15 year old stroke) with recurrent seizures, mild signs of dysarthria, upper left limb paralysis, lower left limb paresis, lack of coordination in the right limbs, severe in the lower right extremity and to a lesser extent in the upper right extremity

He dramatically improved his speech fluency. The left lower limb paresis improved together with an increase in walking autonomy, but he was still unable to flex and extend the left foot rhythmically. Also the right limbs coordination improved. On the contrary, the left upper limb paralysis did not change at all.

34 year old male (17 month old stroke) with global non fluent aphasia with some deficits in the reading comprehension, a complete spastic hemiplegia of the right upper limb with spastic hypertonia, a partial paresis of the right inferior limb (but he was able to walk with some walking aids) and right hemilateral hypoaesthesia

Good improvement in the common everyday acts of his life, as speaking and understanding and also in walking, but not in his upper limb paralysis

Once again, it is important to keep in mind that fMRI imagining confirms long-term these benefits and can play a future role in determining hyperbaric-based protocols for chronic stroke sufferers <view study

Functional MRI (fMRI) Evaluation of Hyperbaric Oxygen Therapy (HBOT) Efficacy in Chronic Cerebral Stroke: A Small Retrospective Consecutive Case Series - PubMed (nih.gov)

HBOT HIGHLY EFFECTIVE TREATMENT FOLLOWING RADIATION THERAPY

September 14, 2022

HBOT HIGHLY EFFECTIVE TREATMENT FOLLOWING RADIATION THERAPY

Radiation therapy is a standard of care for many patients undergoing cancer treatments; however, when pelvic radiation is performed, it’s successes also can come with a debilitating side-effect where the bladder becomes inflamed leading to a painful and bleeding condition called hemorrhagic cystitis (HS). This is a very difficult condition to treat. Promising new research, just published in March 2011, is now giving hope for these sufferers. This study clearly demonstrates successful therapy with long-term follow up when patients were treated with hyperbaric oxygenation therapy. Here, a standard program of just 40 hyperbaric sessions were given to 25 patients who were diagnosed with HS. More importantly, all patients had already failed conventional therapy. So get ready for the results–ALL 25 PATIENTS IMPROVED AND WERE SUCCESSFULLY TREATED. Furthermore, after close to 2 year follow up, no regressions were shown. The results of this study are truly remarkable and makes for a strong argument to add hyperabric oxygenation therapy to standard of care and a primary treatment option for those with HS. The authors of the study support this previous statement by adding in the fact that hyperbaric oxygen is highly effective and safe, non-invasive therapy for HC secondary to pelvic radiation <view study> [Management of hemorrhagic radiation cystitis with hyperbaric oxygen therapy] - PubMed (nih.gov)

How PEMF therapy heals adrenal disorders

September 22, 2022

How PEMF therapy heals adrenal disorders

Hundreds of studies indicate that PEMF therapy heals adrenal disorders. This is great news for those who suffer from adrenal fatigue, and ultimately end up with diabetes, thyroid disease, and other adrenal disorders. How does PEMF therapy work to bring healing to your adrenal glands? PEMF therapy has been shown to boost cortisol. PEMF therapy heals adrenal fatigue by balancing cortisol, meaning that it aids in bringing it back to the appropriate level. You can put PEMF therapy to the test, and discover for yourself how it heals adrenal disorders and can restore the mind and body to good health. Read More PEMF Therapy Education, Jan 18, 2018.

How PEMF therapy repairs the damage from Lyme Disease

September 22, 2022

How PEMF therapy repairs the damage from Lyme Disease

Did you know that the damage from Lyme Disease can have a long-term impact on your health? Lyme Disease can cause short-term damage and repairs long-term damage as it settles into the tissues and organs. The goal is to knock out the infection before it spreads into the tissues and organs, but the infection is not always treated immediately. Oftentimes, someone that has been bit by a tick may not feel it, or they never see a bull’s eye shaped bite on their leg. As the infection grows and settles into the organs and tissues, inflammation and scarring occur, causing damage to those tissues and organs. Antibiotics are always the first course of action, and when those are not given early on the infection continues to grow. PEMF therapy is a viable adjunctive option, and it can be just as powerful as the antibiotics, as well as when used in conjunction with antibiotics.

PEMF therapy has been highly regarded as a safe and non-invasive way to reduce symptoms for numerous diseases and conditions, including damage from Lyme Disease. As electromagnetic waves move down to the cellular level, they can reduce inflammation, improve circulation, and reduce pain. PEMF therapy is a powerful complementary therapy, and this therapy may increase the effectiveness of conventional therapies.

PEMF Therapy Education, May 25, 2017.

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HYPERBARIC OXYGEN INCREASES BDNF — A HOT TOPIC IN BRAIN REGENERATIVE THERAPIES

September 14, 2022

HYPERBARIC OXYGEN INCREASES BDNF — A HOT TOPIC IN BRAIN REGENERATIVE THERAPIES

BDNF is a very powerful protein that is released by your body in the efforts to stimulate the production of brand new brain cells (neurogenesis). This protein is vital to learning, memory, and higher thinking. Moreover, the expression of this protein is significantly reduced in Alzheimer's, Parkinson's, and Huntington's disease. With this understanding, research is now pouring in to help us gain a better understanding of BDNF and its role in brain plasticity and regeneration. Hyperbaric oxygen therapy (HBOT) has been noted for its brain regenerative effects, and this new study supports this notion. Researchers used a lower pressure of 1.5 ATA along with 2.0 ATA, and found that both pressures were able to cause significant increases in BDNF in just 3 to 5 days of consecutive HBOT sessions. “The BDNF concentration increased in a highly significant manner after three consecutive HBO treatments up to 43.94 ng/mL (p < 0.001) and after five HBO treatments up to 51.63 (p < 0.001) when compared to the BDNF concentration after one HBO treatment”. With respect to this study, the purpose was to demonstrate the potential benefits of adding HBOT to cochlear implantation as a promising adjunct treatment for hearing loss. <view study> Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics - PMC

Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients – Randomized, Prospective Trial

September 22, 2022

Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients – Randomized, Prospective Trial

Recovery after stroke correlates with non-active (stunned) brain regions, which may persist for years. The current study aimed to evaluate whether increasing the level of dissolved oxygen by Hyperbaric Oxygen Therapy (HBOT) could activate neuroplasticity in patients with chronic neurologic deficiencies due to stroke. A prospective, randomized, controlled trial including 74 patients (15 were excluded). All participants suffered a stroke 6–36 months prior to inclusion and had at least one motor dysfunction. After inclusion, patients were randomly assigned to “treated” or “cross” groups. Brain activity was assessed by SPECT imaging; neurologic functions were evaluated by NIHSS, ADL, and life quality. Patients in the treated group were evaluated twice: at baseline and after 40 HBOT sessions. Patients in the cross group were evaluated three times: at baseline, after a 2-month control period of no treatment, and after subsequent 2-months of 40 HBOT sessions. HBOT protocol: Two months of 40 sessions (5 days/week), 90 minutes each, 100% oxygen at 2 ATA. We found that the neurological functions and life quality of all patients in both groups were significantly improved following the HBOT sessions while no improvement was found during the control period of the patients in the cross group. Results of SPECT imaging were well correlated with clinical improvement. Elevated brain activity was detected mostly in regions of live cells (as confirmed by CT) with low activity (based on SPECT) – regions of noticeable discrepancy between anatomy and physiology. Conclusions. The results indicate that HBOT can lead to significant neurological improvements in post stroke patients even at chronic late stages. The observed clinical improvements imply that neuroplasticity can still be activated long after damage onset in regions where there is a brain SPECT/CT (anatomy/physiology) mismatch. Efrati S, Fishlev G, Bechor Y, Volkov O, Bergan J, Kliakhandler K, et al. (2013) Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients – Randomized, Prospective Trial. PLoS ONE 8(1): e53716. https://doi.org/10.1371/journal.pone.0053716

HYPERBARIC OXYGEN THERAPY AS AN ADJUNCT FOR FOR ATHLETES

September 14, 2022

HYPERBARIC OXYGEN THERAPY AS AN ADJUNCT FOR FOR ATHLETES

“The best experience of HBO use as a recovery method from muscular fatigue occurred during the Nagano Winter Olympics with seven participating athletes. After physical activity, the athletes received HBOT treatment for 30–40 minutes at 1.3 ATA, with a maximum of six times per athlete and an average of two times per athlete.

An athlete who experienced tension and sharp pain of the abdominal muscles was able to play a game after HBO treatment with almost no pain. Another player who was experiencing anterior knee pain was treated within 2 days of injury and was able to perform afterwards with no difficulty.

These test cases show that HBO treatments demonstrate high performance without adverse effects such as muscular pain and nerve paralysis. Players were also able to benefit from the conditioning effects of HBO treatment” 

HYPERBARIC OXYGEN THERAPY CAN IMPROVE SURGICAL PROCEDURES

September 14, 2022

HYPERBARIC OXYGEN THERAPY CAN IMPROVE SURGICAL PROCEDURES

Ever wonder why some people recover well from surgery and others can have long term implications including infections and even amputations. It is now clear that hypoxia (low oxygen levels) clearly effects the response and recovery following surgery. Local hypoxic conditions account for longer time for healing and greater susceptibility for infections. Treatments with hyperbaric oxygen therapy can reduce the hypoxia in the body and have a substantial effect on reducing negative clinical outcomes, along with shortening the healing time, and reducing chances of infection. Many plastic surgeons are now recognizing the benefits of HBOT in their discipline and referring for HBOT post-op. This is making for better, improve and safer surgical procedures, along with less down time and hospitalization <view study> Oxygen in wound healing: nutrient, antibiotic, signaling molecule, and therapeutic agent - PubMed (nih.gov)

HYPERBARIC OXYGEN THERAPY FOR DEGENERATIVE DISCS

September 14, 2022

HYPERBARIC OXYGEN THERAPY FOR DEGENERATIVE DISCS

Hyperbaric oxygen therapy HBOT is a used to treat difficult wounds in many cutting-edge hospitals and wound centers mainly due to it’s ability to promote growth of new tissue and blood vessels.

Researchers have now taken this further to see if the healing effects of oxygen can also be shown for the intervertebral discs. This is a debilitating condition for a wide range of the population and are seen in more as people age and also for those who have suffered physical trauma to the area (ie, contact sports or accidents and falls).

The following study shows us the mechanism involved in hyperbaric oxygen’s application for treating degenerative discs. Since this treatment modality is non-invasive, it should now get considerable attention for an adjunct treatment modality for disc degeneration <view study>

Effect of hyperbaric oxygenation on intervertebral disc degeneration: an in vitro study with human lumbar nucleus pulposus - PubMed (nih.gov)

HYPERBARIC OXYGEN THERAPY GIVES REMARKABLE IMPROVEMENTS FOR ERECTILE DYSFUNCTION

September 14, 2022

HYPERBARIC OXYGEN THERAPY GIVES REMARKABLE IMPROVEMENTS FOR ERECTILE DYSFUNCTION

A prospective study analyzing 30 men who were diagnosed with ED for more than 6 months were treated with a course of 40 hyperbaric oxygen (HBOT) sessions. The results of this study showed remarkable benefits, even for those men who previously were unsuccessful in achieving erections! After HBOT, 63% of the men had none to mild erectile dysfunction. In addition, both penetration and maintenance of erections improved significantly — 24 of the 30 men (80%) reported improved erections. Furthermore, 7 participants who agreed to undergo penile perfusion MRI pre and post HBOT allowed the researchers to conclude: “HBOT reverses the basic common pathophysiology, atherosclerosis and decreased penile perfusion, responsible for most cases of ED” <view study> Hyperbaric oxygen can induce angiogenesis and recover erectile function | International Journal of Impotence Research (nature.com)

HYPERBARIC OXYGEN THERAPY HELPS 2 YEAR OLD MAKE A FULL RECOVERY

September 14, 2022

HYPERBARIC OXYGEN THERAPY HELPS 2 YEAR OLD MAKE A FULL RECOVERY

A Near Drowning accident left this 2 year old girl in critical condition. After being intensively treated in the hospital, she was finally discharged 35 days following the accident, but still unresponsive to all stimuli. Fortunately, she was able to have access to hyperbaric oxygen therapy and began a series of 40 sessions over 38 days (a total of 78 days following the near drowning). Her recovery was immediate, and the MRI that was previously taken before being discharged from the hospital was nearly completely reversed following the short course of hyperbaric therapy. Most notably for hyperbaric physicians was the dosage of oxygen that was used to achieve these remarkable results. Each session consisted of 45 minutes at 1.3 ATA (mild hyperbaric therapy — mHBOT). Not only was the pressure a lower pressure protocol, but there was no other breathing apparatus used in the treatment, just regular air breathing. This case report is consistent with many others who have had ‘miraculous recovery’ following hyperbaric oxygen therapy. However, this particular case is an excellent one to give the hyperbaric community a wake up and clearly demonstrates the power of mild hyperbaric oxygen therapy. The powerful reversal of severe brain damage demonstrates the effectiveness of mHBOT, as seen in this case (New York Post release) “The brain is very sensitive to even slight changes in oxygen tension and this is one key reason why so many neurological conditions are positively affected by m-HBOT.” Another key factor for this girl’s quick and nearly complete recovery is that she had quick access to hyperbaric oxygen therapy (within 3 months). Timing is everything and generally speaking, the quicker the access, the better the outcome, particularly if this procedure is applied within the first 2 years following brain trauma. Longer courses of hyperbaric therapy may need to be applied for injuries that have exceeded 2 years, as hyperbaric oxygen therapy is gaining widespread publicity for its neurological regenerative effects and stem cell release. The end result of “new brain tissue” now gives new hope for both recent and long-term brain injury survivors

HYPERBARIC OXYGEN THERAPY HELPS TO DRAMATICALLY ALLEVIATE LONG-STANDING PTSD SYMPTOMS IN 35 VETERANS

September 14, 2022

HBOT HELPS TO DRAMATICALLY

HYPERBARIC OXYGEN THERAPY HELPS TO DRAMATICALLY ALLEVIATE LONG-STANDING PTSD SYMPTOMS IN 35 VETERANS

Post Traumatic Stress Disorder (PTSD) affects approximately 3.5 percent of U.S. adults every year, and an estimated one in 11 people will be diagnosed with PTSD in their lifetime. This number being much higher in military veterans and can have long lasting effects, impacting their quality of life.

This study took 35 veterans diagnosed with long-standing PTSD symptoms (greater than 4 years) though a 3 month intensive hyperbaric protocol involving 60 sessions at 2.0 ATA. The results showed a dramatic reduction in PTSD symptoms. Brain imaging thought f-MRI confirmed these improvements following the 3 month course of hyperbaric oxygen therapy (HBOT)<view study>

Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial - PMC (nih.gov)

HYPERBARIC OXYGEN THERAPY HELPS TO IMPROVE AUTISM SYMPTOMS, STUDY SHOWS

September 14, 2022

HYPERBARIC OXYGEN THERAPY HELPS TO IMPROVE AUTISM SYMPTOMS, STUDY SHOWS

Over the past few years, hyperbaric oxygen therapy is being used increasingly by doctors and clinicians for its off-label uses, and autism is one of the largest conditions, particularly for lower pressure protocols.

It is very well known that autistic children will have much higher levels of inflammation presenting in the brain (neuroinflammation). This study looked at lower pressure protocols and followed markers of inflammation.

They found significant improvements with both ambient air and with breathing 100% oxygen, including anti-inflammatory effects. More importantly, they were also able to observe significant clinical benefits and improvements of HBOT<view study>

The effects of hyperbaric oxygen therapy on oxidative stress, inflammation, and symptoms in children with autism: an open-label pilot study - PMC (nih.gov)

HYPERBARIC OXYGEN THERAPY IMPROVES MALE IMPOTENCE

September 14, 2022

HYPERBARIC OXYGEN THERAPY IMPROVES MALE IMPOTENCE

43 patients participated in a study for erectile dysfunction. The participants underwent a series of hyperbaric oxygen sessions for a total of 9 months.

The collected data was very positive and the results of this study confirmed that hyperbaric oxygen therapy HBOT helped to improve erectile function. In addition, they measured both total and free serum testosterone levels and the data did not show any effect on testosterone levels.

This would leave us to believe that the benefits of hyperbaric oxygen are not related to hormonal fluctuations occurring from this procedure, but instead other physiological benefits from the hyperbaric administration <view study>

The impact of hyperbaric oxygen therapy on erectile functions and serum testosterone levels in patients with erectile dysfunction - PubMed (nih.gov)

Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis

October 14, 2022

HBOT improves neurocognitive functions of post-stroke patients

Previous studies have shown that hyperbaric oxygen therapy (HBOT) can improve the motor functions and memory of post-stroke patients in the chronic stage. The aim of this study is to evaluate the effects of HBOT on overall cognitive functions of post-stroke patients in the chronic stage. The nature, type and location of the stroke were investigated as possible modifiers. A retrospective analysis was conducted on patients who were treated with HBOT for chronic stroke (>3 months) between 2008-2018. Participants were treated in a multi-place hyperbaric chamber with the following protocols: 40 to 60 daily sessions, 5 days per week, each session included 90 min of 100% oxygen at 2 ATA with 5 min air brakes every 20 minutes. Clinically significant improvements (CSI) were defined as > 0.5 standard deviation (SD). The study included 162 patients (75.3% males) with a mean age of 60.75±12.91. Of them, 77(47.53%) had cortical strokes, 87(53.7%) strokes were located in the left hemisphere and 121 suffered ischemic strokes (74.6%). HBOT induced a significant increase in all the cognitive function domains (p < 0.05), with 86% of the stroke victims achieving CSI. There were no significant differences post-HBOT of cortical strokes compared to sub-cortical strokes (p > 0.05). Hemorrhagic strokes had a significantly higher improvement in information processing speed post-HBOT (p < 0.05). Left hemisphere strokes had a higher increase in the motor domain (p < 0.05). In all cognitive domains, the baseline cognitive function was a significant predictor of CSI (p < 0.05), while stroke type, location and side were not significant predictors. Conclusions. HBOT induces significant improvements in all cognitive domains even in the late chronic stage. The selection of post-stroke patients for HBOT should be based on functional analysis and baseline cognitive scores rather than the stroke type, location or side of lesion. Hadanny A, Rittblat M, Bitterman M, May-Raz I, Suzin G, Boussi-Gross R, Zemel Y, Bechor Y, Catalogna M, Efrati S. Hyperbaric oxygen therapy improves neurocognitive functions of post-stroke patients – a retrospective analysis. Restor Neurol Neurosci. 2020;38(1):93-107. doi: 10.3233/RNN-190959. PMID: 31985478; PMCID: PMC7081098.

HYPERBARIC OXYGEN THERAPY INCREASES NOREPINEPHRINE LEVELS FOR THE TREATMENT OF PARKINSON’S DISEASE

September 14, 2022

HYPERBARIC OXYGEN THERAPY INCREASES NOREPINEPHRINE LEVELS FOR THE TREATMENT OF PARKINSON’S DISEASE

Tissue concentrations of norepinephrine (NE) are markedly decreased in various regions of the brain in Parkinson patients. Not only is NE involved in cognitive operations, "freezing" of gait, tremor, dyskinesia, REM sleep regulation, and other aspects of brain function, but evidence also suggest its role in the neurodegenerative process itself.

This study discusses the ability of hyperbaric oxygen therapy HBOT to help increases NE levels in the brain; thereby, helping to restore motor deficits in Parkinson’s disease patients <view study>

Hyperbaric Oxygen Therapy Effect on "Kinesia Paradoxa" Brain Circuits - PubMed (nih.gov)

HYPERBARIC OXYGEN THERAPY MAY BE EFFECTIVE TO IMPROVE HYPOXEMIA IN PATIENTS WITH SEVERE COVID-2019 PNEUMONIA: TWO CASE REPORTS

September 14, 2022

HBOT MAY BE EFFECTIVE TO IMPROVE HYPOXEMIA IN PATIENTS WITH SEVERE COVID-2019 PNEUMONIA

Two male patients ages 57 and 64 years old were treated with a 1 week course of hbot at 1.5 ATA (60 minutes per session) Shortness of breath subsided immediately with both patients after the first hyperbaric session and resolved by the end of the 7 days. More notably, neither patient became critically ill and the lung CT scans showed remarkable improvement in lung pathology. The authors of this study concluded this report by suggesting that “hyperbaric oxygen therapy may promptly improve the progressive hypoxemia of patients with COVID-2019 pneumonia” <view study> Hyperbaric oxygen therapy may be effective to improve hypoxemia in patients with severe COVID-2019 pneumonia: two case reports - PubMed (nih.gov)

HYPERBARIC OXYGEN THERAPY REDUCES OPIOID WITHDRAWAL SYMPTOMS

September 14, 2022

HYPERBARIC OXYGEN THERAPY REDUCES OPIOID WITHDRAWAL SYMPTOMS

Even in the era of COVID-19, the opioid crisis stands out as one of this century’s most devastating public health disasters, according to a Stanford-Lancet report published Feb. 2, 2022. According to a recent white house report on March 1, 2022, "Drug overdose deaths have reached a historic high, devastating families and communities".

Hyperbaric oxygen therapy has been widely used in addiction and recovery centers for the vast array of physiological benefits that this procedure can provide  patients undergoing  recovery programs. One of the reported benefits has been in helping to reduce withdrawal symptoms. This study followed 17 adults being treated with medically supervised methadone dose reduction. 

They were also prescribed a short course of 5 daily hyperbaric sessions (90 minute sessions at 2.0 ATA). Withdrawal symptoms were assessed at baseline and daily during the 5-day intervention period. "Opioid withdrawal symptoms were reduced after Day 1 of HBOT by twice as much, on average, compared with the control condition"

HYPERBARIC OXYGEN THERAPY EFFECTIVELY ALLEVIATES WITHDRAWAL SYMPTOMS INDUCED BY MORPHINE DEPENDENCE

Oxygen plays a central role in many pathological and disease states. This has led to a strong emphasis being placed on hyperbaric oxygen therapy (HBOT) to help determine the role of oxygen within these states; moreover, to help determine if extra oxygen can help to improve the pathophysiological processes going on within these disease states.

In this particular study, researchers looked at oxygen's role in detoxification and its use for withdrawal symptoms in a morphine-dependent rat model. Through the evaluation of withdrawal symptom scores, biochemical indices and neurotransmitters, they found that HBOT was able to cause a significant reduction in both withdrawal symptoms and weight loss.

Along with these benefits many key pathophysiological markers including dopamine and other neurotransmitter changes, also showed significant improvements. Together, these findings led the researchers to conclude that HBOT can effectively alleviate withdrawal symptoms induced by morphine dependence.

Currently, there are many drug and alcohol centres that are using HBOT for a wide variety of uses, one of which is for addiction control. This study gives us a little more insight into their rationale and potential benefits <view study>

Hyperbaric Oxygen Attenuates Withdrawal Symptoms by Regulating Monoaminergic Neurotransmitters and NO Signaling Pathway at Nucleus Accumbens in Morphine-Dependent Rats - PubMed (nih.gov)

HYPERBARIC OXYGEN THERAPY SHOWN TO HELP WITH AUTISM

September 14, 2022

HYPERBARIC OXYGEN THERAPY SHOWN TO HELP WITH AUTISM

“Children with autism who received hyperbaric treatment at 1.3 ATA and 24% oxygen for 40 hourly sessions had significant improvements in overall functioning, receptive language, social interaction, eye contact, and sensory/cognitive awareness compared to children who received slightly pressurized room air...” <view study> Hyperbaric treatment for children with autism: a multicenter, randomized, double-blind, controlled trial | BMC Pediatrics | Full Text (biomedcentral.com)

Hyperoxia preconditioning: the next frontier in neurology?​

September 22, 2022

Hyperoxia preconditioning: the next frontier in neurology?

Oxygen is indispensable for all aerobic organisms and has become one of the most widely used therapeutic agents. Currently, oxygen not only is applied in the treatment of diseases, but becomes a modality for the prevention of some diseases. Hyperoxia preconditioning with normobaric or hyperbaric oxygen has been found to be protective in some diseases in several animal models and clinical trials. Currently, investigators pay increasing attention to the application of hyperoxia preconditioning in the prevention of common neurological diseases, and encouraging effectiveness has been achieved. In the present short review, we briefly described the development, application and mechanisms of hyperoxia preconditioning the next frontier in the neurology, and the issues in future application of hyperoxia preconditioning were also proposed.

Shanshan Duan, Guiqiang Shao, Ling Yu, Chuancheng Ren. (2015) Angiogenesis contributes to the neuroprotection induced by hyperbaric oxygen preconditioning against focal cerebral ischemia in rats. International Journal of Neuroscience 125:8, pages 625-634.

IMPROVING BONE REGENERATION WITH HYPERBARIC OXYGEN THERAPY

September 14, 2022

IMPROVING BONE REGENERATION WITH HYPERBARIC OXYGEN THERAPY

Poor Bone healing is one of the many associated health concerns for diabetics, who are known to have a reduced ability to form bone and have poor bone quality, thus influencing bone healing.

Since hyperbaric oxygen HBOT has been used for a variety of diabetic-related conditions including poor wound healing, researchers in this study decided to observe the bone healing effects of hyperbaric oxygen therapy over a short 7 day duration.

The results showed favorable improvements in bone regeneration and these findings were subsequently published in this journal <view study>

Hyperbaric Oxygen therapy effects on bone regeneration in Type 1 diabetes mellitus in rats - PubMed (nih.gov)

Local negative pressure and magnetic field in therapy of patients with erectile dysfunction

September 22, 2022

Local negative pressure and magnetic field in therapy of patients with erectile dysfunction

Combined treatment with local negative pressure and pulsating magnetic field conducted in 116 patients with erectile dysfunction aged 20-60 years produced optimal treatment results. Recovery and improvement of the erectile function were achieved in 85.7% patients given local vacuum-magnetotherapy.

Karpukhin IV, Kazantsev SN. [Local negative pressure and magnetic field in therapy of patients with erectile dysfunction]. Vopr Kurortol Fizioter Lech Fiz Kult. 2007 Jul-Aug;(4):35-8. Russian. PMID: 17882824.

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Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke

October 14, 2022

Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke

Several studies have provided evidence with regard to the neuroprotection benefits of hyperbaric oxygen (HBO) therapy in cases of stroke, and HBO also promotes bone marrow stem cells (BMSCs) proliferation and mobilization. This study investigates the influence of HBO therapy on the migration of BMSCs, neurogenesis, gliosis, and inflammation after stroke. Rats that sustained transient middle cerebral artery occlusion (MCAO) were treated with HBO three weeks or two days. The results were examined using a behavior test (modified neurological severity score, mNSS) and immunostaining to evaluate the effects of HBO therapy on migration of BMSCs, neurogenesis, and gliosis, and expression of neurotrophic factors was also evaluated. There was a lower mNSS score in the three-week HBO group when compared with the two-day HBO group. Mobilization of BMSCs to an ischemic area was more improved in long course HBO treatments, suggesting the duration of therapy is crucial for promoting the homing of BMSCs to ischemic brain by HBO therapies. HBO also can stimulate expression of trophic factors and improve neurogenesis and gliosis. These effects may help in neuronal repair after ischemic stroke, and increasing the course of HBO therapy might enhance therapeutic effects on ischemic stroke. Lee YS, Chio CC, Chang CP, Wang LC, Chiang PM, Niu KC, Tsai KJ. Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke. Mediators Inflamm. 2013;2013:512978. doi: 10.1155/2013/512978. Epub 2013 Feb 21. PMID: 23533308; PMCID: PMC3595722.

Low frequency pulsed electromagnetic field — A viable alternative therapy for arthritis

September 21, 2022

Low frequency pulsed electromagnetic field — A viable alternative therapy for arthritis

Arthritis refers to more than 100 disorders of the musculoskeletal system. The existing pharmacological interventions for arthritis offer only symptomatic relief and they are not definitive and curative. Magnetic healing has been known from antiquity and it is evolved to the present times with the advent of electromagnetism. The original basis for the trial of this form of therapy is the interaction between the biological systems with the natural magnetic fields. Optimization of the physical window comprising the electromagnetic field generator and signal properties (frequency, intensity, duration, waveform) with the biological window, inclusive of the experimental model, age and stimulus has helped in achieving consistent beneficial results. Low frequency pulsed electromagnetic field (PEMF) can provide noninvasive, safe and easy to apply method to treat pain, inflammation and dysfunctions associated with rheumatoid arthritis (RA) and osteoarthritis (OA) and PEMF has a long term record of safety. This review focusses on the therapeutic application of PEMF in the treatment of these forms of arthritis. The analysis of various studies (animal models of arthritis, cell culture systems and clinical trials) reporting the use of PEMF for arthritis cure has conclusively shown that PEMF not only alleviates the pain in the arthritis condition but it also affords chondroprotection, exerts antiinflammatory action and helps in bone remodeling and this could be developed as a viable alternative for arthritis therapy. Ganesan K, Gengadharan AC, Balachandran C, Manohar BM, Puvanakrishnan R. Low frequency pulsed electromagnetic field–a viable alternative therapy for arthritis. Indian J Exp Biol. 2009 Dec;47(12):939-48. PMID: 20329696. Source

LOW PRESSURE HYPERBARICS IMPROVES CEREBRAL BLOOD FLOW IN FIREFIGHTERS WITH MILD TBI AND EMOTIONAL DISTRESS

September 14, 2022

LOW PRESSURE HYPERBARICS IMPROVES CEREBRAL BLOOD FLOW IN FIREFIGHTERS WITH MILD TBI AND EMOTIONAL DISTRESS

Twenty firefighters with mTBI and mild emotional distress were treated with HBO at a relatively low pressure of 1.3 atmospheres absolute for 45 min a day for 20 consecutive day. The goal of the study was to evaluate the subsequent changes in the regional improves cerebral blood flow (rCBF) of the limbic system in these firefighters.

The results showed an increase in rCBF in the hippocampal and parahippocampal regions of the brain. This may explain the recent evidence that suggests the ability for HBOT to help neural activities in the human brain and subsequently improve symptoms of psychiatric disorders <view study>

Hippocampal cerebral blood flow increased following low-pressure hyperbaric oxygenation in firefighters with mild traumatic brain injury and emotional distress - PubMed (nih.gov)

Low-frequency Pulsed Electromagnetic Field Therapy in Fibromyalgia

September 22, 2022

Low-frequency Pulsed Electromagnetic Field Therapy in Fibromyalgia

This study evaluated the clinical effectiveness of low-frequency pulsed electromagnetic field (PEMF) therapy for women with fibromyalgia (FM). Fifty-six women with FM, aged 18 to 60 years, were randomly assigned to either PEMF or sham therapy. Both the PEMF group (n=28) and the sham group (n=28) participated in therapy, 30 minutes per session, twice a day for 3 weeks. Treatment outcomes were assessed by the fibromyalgia Impact questionnaire (FIQ), visual analog scale (VAS), patient global assessment of response to therapy, Beck Depression Inventory (BDI), and Short-Form 36 health survey (SF-36), after treatment (at 4 wk) and follow-up (at 12 wk). The PEMF group showed significant improvements in FIQ, VAS pain, BDI score, and SF-36 scale in all domains at the end of therapy. These improvements in FIQ, VAS pain, and SF-36 pain score during follow-up. The sham group also showed improvement were maintained on all outcome measures except total FIQ scores after treatment. At 12 weeks follow-up, only improvements in the BDI and SF-36 scores were present in the sham group. In conclusion, this study showed that low-frequency PEMF therapy might improve function, pain, fatigue, and global status in FM patients. Sutbeyaz, Serap Tomruk MD; Sezer, Nebahat MD; Koseoglu, Fusun MD; Kibar, Sibel MD Low-frequency Pulsed Electromagnetic Field Therapy in Fibromyalgia, The Clinical Journal of Pain: October 2009 – Volume 25 – Issue 8 – p 722-728 doi: 10.1097/AJP.0b013e3181a68a6c Source

LOW-PRESSURE HYPERBARIC OXYGEN HELPS BLAST-INDUCED INJURED MILITARY SUBJECTS WITH POST CONCUSSION DISORDER AND PTSD

September 14, 2022

LOW-PRESSURE HYPERBARIC OXYGEN HELPS BLAST-INDUCED INJURED MILITARY SUBJECTS WITH POST CONCUSSION DISORDER AND PTSD

16 military subjects received a 'typical dose' of low pressure hyperbaric oxygen therapy (40 sessions at 1.5 ATA for 60 min HBOT within 30 days) for mild to moderate traumatic brain injuries. After treatment, they demonstrated significant improvement in impulsivity, mood, anxiety, quality of life scores, and more. Their SPECT brain scans showed remarkable overall improvement in blood flow. These results were confirmed with brain imaging scans which showed remarkable improvements in blood flow to these regions of the brain, following the course of treatments. <view studyA phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder - PubMed (nih.gov)

LOW-PRESSURE HYPERBARIC OXYGEN TREATMENT HELPS WOMEN WITH FIBROMYALGIA

September 14, 2022

LOW-PRESSURE HYPERBARIC OXYGEN TREATMENT HELPS WOMEN WITH FIBROMYALGIA

This study was used to evaluate the effects of low-pressure hyperbaric oxygen therapy (HBOT) on fatigue, pain, endurance and functional capacity, physical performance and cortical excitability when compared with a physical exercise program in women with fibromyalgia. The hyperbaric protocol used was a 2 month course of daily 90 minute sessions (5 days per week for a total of 40 hours) at 1.45 ATA. During this time period, 60 minutes of low intensity exercises, twice weekly (for a total of 16 sessions), was included in the protocol. This group of participants showed improvements in pressure pain threshold, endurance and functional capacity, as well as physical performance. In addition, the HBOT group reported significant improvements in induced fatigue and perceived pain at rest. <view study> Comparative study of the effectiveness of a low-pressure hyperbaric oxygen treatment and physical exercise in women with fibromyalgia: randomized clinical trial - PMC (nih.gov)

Mechanisms and therapeutic applications of electromagnetic therapy in Parkinson’s disease

September 22, 2022

Mechanisms and therapeutic applications of electromagnetic therapy in Parkinson’s disease

Electromagnetic therapy is a non-invasive and safe approach for the management of several pathological conditions including neurodegenerative diseases. Parkinson’s disease is a neurodegenerative pathology caused by abnormal degeneration of dopaminergic neurons in the ventral tegmental area and substantia nigra pars compacta in the midbrain resulting in damage to the basal ganglia. Electromagnetic therapy has been extensively used in the clinical setting in the form of transcranial magnetic stimulation, repetitive transcranial magnetic stimulation, high-frequency transcranial magnetic stimulation and pulsed electromagnetic field therapy which can also be used in the domestic setting. In this review, we discuss the mechanisms and therapeutic applications of electromagnetic therapy to alleviate motor and non-motor deficits that characterize Parkinson’s disease. Vadalà, M., Vallelunga, A., Palmieri, L. et al. Mechanisms and therapeutic applications of electromagnetic therapy in Parkinson’s disease. Behav Brain Funct 11, 26 (2015). https://doi.org/10.1186/s12993-015-0070-z Source

Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology

September 22, 2022

Mechanisms and therapeutic effectiveness of pulsed electromagnetic field therapy in oncology

Cancer is one of the most common causes of death worldwide. Available treatments are associated with numerous side effects and only a low percentage of patients achieve complete remission. Therefore, there is a strong need for new therapeutic strategies. In this regard, Mechanisms and therapeutic effectiveness pulsed electromagnetic field (PEMF) therapy presents several potential advantages including non-invasiveness, safety, lack of toxicity for non-cancerous cells, and the possibility of being combined with other available therapies. Indeed, PEMF stimulation has already been used in the context of various cancer types including skin, breast, prostate, hepatocellular, lung, ovarian, pancreatic, bladder, thyroid, and colon cancer in vitro and in vivo. At present, only limited application of PEMF in cancer has been documented in humans. The referenced article reviews the experimental and clinical evidence of PEMF therapy discussing future perspectives in its use in oncology.

In conclusion, only two clinical studies have used PEMF therapy for cancer treatment. These studies show that PEMF therapy is safe and promising compared to other available cancer therapies. In the future, PEMFs could be used not only as primary therapy but also in combination with other common antineoplastic therapies.
Given that new portable and affordable PEMF devices are increasingly available on the market, future controlled clinical studies are expected to further determine the
potential of PEMF therapy in oncology.

Maria Vadalà, Julio Cesar Morales-Medina, Annamaria Vallelunga, Beniamino Palmieri, Carmen Laurino & Tommaso Iannitti, Cancer Medicine 2016; 5(11):3128–3139 doi: 10.1002/cam4.861

Source

MILD HYPERBARIC OXYGEN THERAPY BENEFITS FOR DIABETICS

September 14, 2022

MILD HYPERBARIC OXYGEN THERAPY BENEFITS FOR DIABETICS

Now published in the 2018 Journal of Diabetes, research confirms some of the recently noted benefits of mild hyperbaric oxygen (m-HBOT) therapy for diabetics. Specifically, in lowering fasting and non-fasting glucose, HbA1c, and triglyceride levels; all of which are important markers leading to advanced disease states associated with this diabetes. Researchers also focused on skeletal muscle activity and fibers, and found that m-HBOT was able to help the muscle’s natural ability to use oxygen (which is typically compromised in diabetics). By helping to sensitize sugar metabolism and oxygen use within the skeletal muscles, m-HBOT can provide a significant benefit for people with diabetes. It should be noted however, that this protocol provided rats with m-HBOT daily (3 hours per day) for 22 consecutive weeks (about 5 months). <view study> Mild hyperbaric oxygen inhibits the growth-related decline in skeletal muscle oxidative capacity and prevents hyperglycemia in rats with type 2 diabetes mellitus - PubMed (nih.gov)

Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields

September 21, 2022

Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pemf

Non-depolarizing magnetic fields, like low frequency-pulsed electromagnetic fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels on cellular membranes. Recently, the CTU Mega 20 device was presented as a molecular accelerator, using energy up to 200 J and providing high-power (2 Tesla) pulsating fields with a water-repulsive (diamagnetic) action and tissue biostimulation. We tested the hypothesis that LF-PEMFs could modulate long-term corticospinal excitability in healthy brains by applying CTU Mega 20®. Ten healthy subjects without known neurological and/or psychiatric diseases entered the study. A randomized double-blind sham-controlled crossover design was employed, recording TMS parameters (amplitude variation of the motor evoked potential as index of cortical excitability perturbations of the motor system) before (pre) and after (post + 0, + 15, + 30 min) a single CTU Mega 20 session on the corresponding primary right-hand motor area, using a real (magnetic field = 2 Tesla; intensity = 90 J; impulse frequency = 7 Hz; duration = 15 min) or sham device. A two-way repeated measures ANOVA with TIME (pre, post + 0, + 15, + 30 min) and TREATMENT (real vs. sham stimulation) as within-subjects factor was applied.

Conclusions. Our proof-of-concept study in healthy subjects supports the idea that non-ionizing LF-PEMFs induced by the CTU Mega 20 diamagnetic acceleration system could represent a new approach for brain neuromodulation. Further studies to optimize protocol parameters for different neurological and psychiatric conditions are warranted.

Premi, E., Benussi, A., La Gatta, A. et al. Modulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields(pemf). BMC Neurosci 19, 34 (2018). https://doi.org/10.1186/s12868-018-0434-z

Source

 

MOVE OVER PROZAC HYPERBARIC OXYGEN DEMONSTRATES ITS ANTI-DEPRESSANT EFFECTS

September 14, 2022

MOVE OVER PROZAC HYPERBARIC OXYGEN DEMONSTRATES ITS ANTI-DEPRESSANT EFFECTS

If you are suffering from depression and have had a past history of head injury or concussion, then pay close attention to a new study published in the Journal of World Neurosurgery, 2017.

It is very well known that 50% of those people that are afflicted with a traumatic brain injury (TBI) will also suffer from major depression and be put on antidepressants like Prozac. However, this and many other reasons for depression, are clearly related to inflammation inside the brain (neuroinflammation).

With knowledge of this information, along with the understanding of the anti-inflammatory properties of hyperbaric oxygen therapy (HBOT) in the brain, researchers carried out a study to help us evaluate and see if HBOT could provide relief for TBI victims suffering from depression. The results demonstrates that HBOT was able to significantly diminish TBI-induced depression-like behavior, through its anti-inflammatory Depressants effects in the brain. <view study>

Hyperbaric Oxygen Effects on Depression-Like Behavior and Neuroinflammation in Traumatic Brain Injury Rats - PubMed (nih.gov)DE

NEW BRAIN TISSUE GROWTH OCCURS FROM LONG COURSE OF HYPERBARIC OXYGEN

September 14, 2022

NEW BRAIN TISSUE GROWTH OCCURS FROM LONG COURSE OF HYPERBARIC OXYGEN

Hyperbaric oxygen therapy is widely used as an effective off-label use for stroke victims. Research has found that this therapy not only targets oxygenation of the effected area and reduces inflammation, but also has been shown to promote bone marrow stem cells (BMSCs) to proliferate and mobilize, which essentially becomes an important part of the neurogenic (nervous system growth) effects that have been demonstrated from hyperbaric procedures. Mobilization of these BMSCs to the damaged areas were more improved in long course hyperbaric treatments, suggesting the duration of therapy is crucial for promoting their neurogenic effects. It is important to also note that emerging stem cell research has clearly demonstrated that BMSCs secrete brain-derived neurotrophic factor (BDNF) and the addition of anti-BDNF neutralising antibodies to MSC-conditioned medium attenuated its neuroprotective effect <view study> This study also looked at the release of BDNF and found that a 3 week course of HBOT was able to produce significantly higher levels of BDNF and GDNF, than shorter 2 day course of HBO. These results indicated that longer and repetitive HBO therapy promoted more neurotrophic factor production, including BDNF and GDNF. <view study> Long course hyperbaric oxygen stimulates neurogenesis and attenuates inflammation after ischemic stroke - PubMed (nih.gov)

OPIOID RECEPTORS SHOWN TO BE PART OF HYPERBARIC OXYGEN’S PAIN-RELIEVING EFFECTS

September 14, 2022

OPIOID RECEPTORS SHOWN TO BE PART OF HYPERBARIC OXYGEN’S PAIN-RELIEVING EFFECTS

Recent research has shown that hyperbaric oxygen therapy (HBOT) can help alleviate pain both in acute and chronic cases. Much attention has focused on the anti-inflammatory effects of HBOT and associated reductions in pain. This study, published in the European Journal of Pain in 2014, showed that opioid receptors may also have a big role in the positive effects of HBOT <view study> Reduced antinociceptive responsiveness to hyperbaric oxygen in opioid-tolerant mice - PubMed (nih.gov)

Optimization of a therapeutic electromagnetic field (EMF) to retard breast cancer tumor growth and vascularity

September 22, 2022

Optimization of a therapeutic electromagnetic field (EMF) to retard breast cancer tumor growth and vascularity

This study provided additional data on the effects of a therapeutic electromagnetic field (EMF) device on growth and vascularization of murine 16/C mammary adenocarcinoma cells implanted in C3H/HeJ mice. Optimization of a Therapeutic EMF treatment significantly suppressed tumor growth in all 7 EMF treated groups. Exposure to 20mT for 10 minutes twice a day was the most effective retard breast cancer tumor growth suppressor vascularity. The effect of EMF treatment on extent of tumor vascularization, necrosis and viable area was determined after euthanasia. The EMF reduced the vascular (CD31 immunohistochemically positive) volume fraction and increased the necrotic volume of the tumor. Treatment with 15 mT for 10 min/d gave the maximum anti-angiogenic effect. Lack of a significant correlation between tumor CD 31 positive area and tumor growth rate indicates a mechanism for suppression of tumor growth in addition to suppression of tumor vascularization.

Conclusion. It is proposed that EMF therapy aimed at suppression of tumor growth and vascularization may prove a safe alternative for patients whether they are or are not candidates for conventional cancer therapy.

Ivan L Cameron, Marko S Markov, W Elaine Hardman Cancer Cell Int. 2014; 14: 125. Published online 2014 Dec 7. doi: 10.1186/s12935-014-0125-5 PMCID: PMC4272545

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PEMF and relief of hypoxia‐induced neuronal cell death: The signaling pathway

October 14, 2022

Pulsed electromagnetic field and relief of hypoxia‐induced neuronal cell death: The signaling pathway

Low‐energy low‐frequency pulsed electromagnetic fields (PEMFs) exert several protective effects, such as the regulation of kinases, transcription factors as well as cell viability in both central and peripheral biological systems. However, it is not clear on which bases they affect neuroprotection and the mechanism responsible is yet unknown. In this study, we have characterized in nerve growth factor‐differentiated pheochromocytoma PC12 cells injured with hypoxia: (i) the effects of PEMF exposure on cell vitality; (ii) the protective pathways activated by PEMFs to relief neuronal cell death, including adenylyl cyclase, phospholipase C, protein kinase C epsilon and delta, p38, ERK1/2, JNK1/2 mitogen‐activated protein kinases, Akt and caspase‐3; (iii) the regulation by PEMFs of prosurvival heat‐shock proteins of 70 (HSP70), cAMP response element‐binding protein (CREB), brain‐derived neurotrophic factor (BDNF), and Bcl‐2 family proteins. The results obtained in this study show a protective effect of PEMFs that are able to reduce neuronal cell death induced by hypoxia by modulating p38, HSP70, CREB, BDNF, and Bcl‐2 family proteins. Specifically, we found a rapid activation (30 min) of p38 kinase cascade, which in turns enrolles HSP70 survival chaperone molecule, resulting in a significant CREB phosphorylation increase (24 hr). In this cascade, later (48 hr), BDNF and the antiapoptotic pathway regulated by the Bcl‐2 family of proteins are recruited by PEMFs to enhance neuronal survival. This study paves the way to elucidate the mechanisms triggered by PEMFs to act as a new neuroprotective approach to treat cerebral ischemia by reducing neuronal cell death. Stefania Gessi, Stefania Merighi, Serena Bencivenni, Enrica Battistello, Fabrizio Vincenzi, Stefania Setti, Matteo Cadossi, Pier Andrea Borea, Ruggero Cadossi, Katia Varani. Journal of Cellular Physiology, January 17, 2019, https://doi.org/10.1002/jcp.28149.

PEMF Therapy Accelerates Wound Healing in Numerous Studies

September 22, 2022

PEMF Therapy Accelerates Wound Healing in Numerous Studies

PEMF therapy can be instrumental in the healing of chronic wounds. There are far less studies on the use of PEMF therapy for the benefit of wound healing than there are for other types of injury. However, the evidence is clear that PEMF therapy has a tremendous impact on the process by which this healing occurs. PEMF therapy accelerates wound healing because it has been shown to stimulate the regeneration of nerves and tissues. The FDA approved the use of PEMF therapy for the healing of delayed and non-union fractures, but at this time the FDA has still not given the approval to use this as a prescribed treatment for wound healing IN Numerous.

There are many types of wounds that may benefit from this therapy including:

  • acute wounds
  • bed sores
  • diabetic ulcers
  • post-operative wounds
  • pressure wounds
  • vascular ulcers

Source

PEMF Therapy Aids in Stroke Recovery

September 22, 2022

PEMF Therapy Aids in Stroke Recovery

A stroke occurs when the blood supply to part of the brain is reduced, depriving brain tissue of oxygen and nutrients. Within minutes, brain damage can occur. After a stroke, many experience partial or complete paralysis of one side of the body. Some experience partial numbness in the fingers and face. More extreme cases of brain damage may experience loss of the ability to walk, talk and function independently. Is there a more effective way to aid in stroke recovery?

The health community often ponders the most effective way to offer rehabilitation after a stroke. Conventional treatment methods take time and can be slow and painstaking. There remains a wonder over whether or not a better treatment option exists. Most commonly, doctors prescribe a combination of medication and physical therapy following a stroke. While these conventional methods are necessary, researchers believe that PEMF therapy can enhance efficacy and accelerate recovery time.

PEMF IS AN EFFECTIVE COMPLIMENTARY THERAPY POST STROKE
PEMF therapy Aids can assist those recovering from a stroke in a number of ways. By improving energy and circulation, PEMF therapy allows for a more active role in rehabilitation. However, the most substantial way PEMF therapy assists with stroke recovery is by improving the function of nerve cells. When nerve cells misfire, motor control issues arise. This is the brain’s way of telling the body that there is injury or damage present.

COMBINING THERAPIES FOR MAXIMUM EFFECTIVENESS
On its own, PEMF therapy will not bring full recovery. However, PEMF can aid in acceleration of stroke recovery when used in combination with conventional medical treatments. In a study pertaining to the combined efficacy of PEMF therapy with Physical Therapy (PT), participants received 1 Hz of PEMF over the healthy side of the brain 10 times daily. The researchers found that administering PEMF prior to daily PT allowed for re-balancing of motor excitability. Essentially, the damaged part of the brain was more likely to react well to physical therapy when primed with PEMF therapy prior to the PT session.

Read more

PEMF Therapy Education, Jul 25, 2019.

PEMF Therapy Boosts Energy for MS Patients

September 22, 2022

PEMF Therapy Boosts Energy for MS Patients

Fatigue can plague those who suffer from multiple sclerosis (MS), but a study shows that PEMF therapy boosts energy for MS patients. The goal of the study was to address multiple symptoms of MS patients, including bladder problems, spasticity (muscle spasms), fatigue, and their overall quality of life. These patients received daily exposure to a PEMF device that was portable. This device was most likely a small, hand-held device. The study does not indicate what settings were used, and for how long. However, lower settings between 3-5 Hz for about 10 minutes are good for relaxation. The MS Quality of Life Inventory was used to measure the results. This showed that 81% of those who completed their sessions, said that PEMF therapy boosts energy. It is important to note, that because MS is the result of damage to the myelin sheath, that the nerve cells can become inflamed around the brain, spinal cord, and elsewhere. Letting the entire body have a taste of PEMF therapy throughout may well result in improvement in other symptoms. The very fact that PEMF therapy boosts energy is encouraging. Read More PEMF Therapy Education, Mar 21, 2018.

PEMF Therapy for Pain Relief

September 22, 2022

PEMF Therapy for Pain Relief

When it comes to managing chronic pain, PEMF therapy for pain relief is a powerful tool. Are you new to the world of PEMF therapy? If so, you may have some questions about what it is, how it works, or what a session is like. Let’s look at some of the frequently asked questions regarding PEMF therapy in regards to pain. Join us, and learn more about how this treatment can help you. PEMF is an acronym for Pulsed Electro-Magnetic Field. PEMF therapy consists of a device which emits pulses of energy waves. This energy courses through the body, directly to damaged or injured areas. The energy is particularly drawn to areas experiencing chronic pain and inflammation. The energy of the PEMF device passes through the cells in your body, amplifying the cellular energy. The increase in energy promotes a natural reaction that regenerates and enhances the efficiency of the cell’s function. This natural process stimulates healing and helps to improve your overall well-being. There are different types of PEMF therapy devices. The type of device best suited for you will depend on your needs and preferred method of application. PEMF mats rest on a table, floor or bed. The mats allow the user to lay directly on the PEMF device and have electromagnetic pulses course throughout the entire body. These devices are a popular option for folks suffering from chronic pain and inflammation. The full body mat energizes all of the cells in your body/ Other accessory PEMF devices provide more direct pulses of energy for localized pain. For example, if you are having difficulties with pain in your knee joint, a PEMF ring is a beneficial option for delivery of pulses directly to the joint. The application process is simple and easy. There is no need for special preparation or chemical numbing agents. Simply order a PEMF device that is appropriate for your needs. As soon as your product arrives, you may start using it in the comfort and privacy of your home. In most cases, PEMF therapy does not cause side effects. It’s a safe therapy that most people use with little to no negative effects. Physicians do not recommend PEMF therapy for people with pacemakers or other electrical implants. Studies show that, in rare cases, certain types of PEMF devices can interfere with the electronics in pacemakers. Because of this, we recommend consulting with your doctor before using a PEMF device if you have a pacemaker. Most of the problems with pacemakers occur with the use of high intensity PEMF devices which are not common for in home use. Hopefully, this has helped you learn more about PEMF therapy and how it offers relief from conditions like fibromyalgia, muscle pain, arthritis, and musculoskeletal pain.  PEMF therapy is a great option for natural, chemical free pain relief and overall wellness.   Read more PEMF Therapy Education, Apr 29, 2019.

POST-EXERCISE HYPERBARIC OXYGENATION IMPROVES RECOVERY FOR SUBSEQUENT PERFORMANCE

September 14, 2022

POST-EXERCISE HYPERBARIC OXYGENATION IMPROVES RECOVERY FOR SUBSEQUENT PERFORMANCE

Post exercise recovery  plays an important role in the overall performance of athletes. This study evaluated the use of hyperbaric oxygen therapy (75 minutes at 1.3 ATA) following fatigue-inducing exercise on a group of training cyclists. Improvements were seen in cycling output power, along with HRV recovery. The results “suggests that HBO is an efficient strategy to improve cardiac parasympathetic reactivation and is beneficial for subsequent performance”

PRECONDITIONING THE BRAIN WITH HYPERBARIC OXYGEN THERAPY BEFORE STROKE/TBI TO REDUCE THE DAMAGE

September 14, 2022

PRECONDITIONING THE BRAIN WITH HYPERBARIC OXYGEN THERAPY BEFORE STROKE

Currently, there is a great deal of focus and attention being put on hyperbaric oxygen therapy, due to the promising results seen in clinical research and the potential application that this can have for those individuals who have suffered a stroke or TBI. Now, there is strong evidence supporting the use of hyperbaric oxygen therapy BEFORE brain trauma or injury, by preconditioning the brain with hyperbaric oxygen therapy. This study shows that HBOT preconditioning stands as a robust prophylactic treatment for the sequestration of inflammation inherent in stroke and TBI. Though we can't predict when the brain will be under traumatic stress (unless it's a planned surgical procedure),  hyperbaric oxygen may become one of the best ways to protect our brain from future injuries. The following groups of individuals would be the ones that would most likely benefit:
  • Athletes and contact sports affecting the head
  • Patients undergoing planned brain surgery
  • High-risk stroke patients
  • Those who are at risk for neuro-degenerative conditions
  • Elderly
The future holds bright for the application of hyperbaric oxygen therapy for being part of both the treatment of brain trauma and for the prevention of the severity of damage that can subsequently occur <view studyProphylactic treatment of hyperbaric oxygen treatment mitigates inflammatory response via mitochondria transfer - PubMed (nih.gov)

Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders

September 22, 2022

Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders

Increasing evidence suggests that an exogenous electromagnetic field might be involved in many biologic processes which are of great importance for therapeutic interventions. Pulsed electromagnetic fields (PEMFs) are known to be a noninvasive, safe and effective therapy agent without apparent side effects. Numerous studies have shown that PEMFs possess the potential to become a stand-alone or adjunctive treatment modality for treating musculoskeletal disorders. However, several issues remain unresolved. Prior to their widely clinical application, further researches from well-designed, high-quality studies are still required to standardize the treatment parameters and derive the optimal protocol for health-care decision making. In this review, we aim to provide current evidence on the mechanism of action, clinical applications, and controversies of PEMFs in musculoskeletal disorders. Highlights are that pulsed electromagnetic fields (PEMFs) are a noninvasive, safe and effective physical therapy, with no significant side effects and that PEMFs provide a new alternative for the treatment of various musculoskeletal disorders. Further study is warranted to confirm the benefits of PEMF therapy on a variety of musculoskeletal disorders. Hongzhi Hu, Wenbo Yang, Qianwen Zeng, Wei Chen, YanBin Zhu, Weijian Liu, Shangyu Wang, Baichuan Wang, Zengwu Shao, Yingze Zhang, Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders, Biomedicine & Pharmacotherapy, Volume 131, 2020, 110767, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2020.110767. Source

Pulsed Electromagnetic Field (PEMF) Therapy in Glaucoma

September 22, 2022

Pulsed Electromagnetic Field (PEMF) Therapy in Glaucoma

Courses of magnetotherapy (MT) using ATOS device with 33 mT magnetic field induction were administered to 31 patients (43 eyes) with primary open-angle glaucoma with compensated intraocular pressure. The operation mode was intermittent, with 1.0 to 1.5 Hz field rotation frequency by 6 radii. The procedure is administered to a patient in a sitting posture with magnetic inductor held before the eye. The duration of a session is 10 min, a course consists of 10 sessions. Untreated eyes (n = 15) of the same patients were examined for control. The patients were examined before and 4 to 5 months after MT course. Vision acuity improved by 0.16 diopters, on an average, in 29 eyes (96.7%) out of 30 with vision acuity below 1.0 before treatment. Visocontrastometry was carried out using Visokontrastometer-DT device with spatial frequency range from 0.4 to 19 cycle/degree (12 frequencies) and 125 x 125 monitor. The orientation of lattices was horizontal and vertical. The contrasts ranged from 0.03 to 0.9 (12 levels). MT brought about an improvement of spatial contrast sensitivity by at least 7 values of 12 levels in 22 (84.6%) out of 26 eyes and was unchanged in 4 eyes. Visual field was examined using Humphry automated analyzer. A 120-point threshold test was used. After a course of MT, visual field deficit decreased by at least 10% in 31 (72%) out of 43 eyes, increased in 3, and was unchanged in 9 eyes; on an average, visual field deficit decreased by 22.4% vs. the initial value. After 4 to 5 months the changes in the vision acuity and visual field deficit were negligible. In controls these parameters did not appreciably change over the entire follow-up period. Bisvas Shutanto Kumar, Listopadova NA. Possibilities of magnetotherapy in stabilization of visual function in patients with glaucoma. Vestn Oftalmol. 1996 Jan-Mar;112(1):6-8. Source

Pulsed electromagnetic field and relief of hypoxia‐induced neuronal cell death

September 22, 2022

Pulsed electromagnetic field and relief of hypoxia‐induced neuronal cell death: The signaling pathway

Low‐energy low‐frequency pulsed electromagnetic fields (PEMFs) exert several protective effects, such as the regulation of kinases, transcription factors as well as cell viability in both central and peripheral biological systems. However, it is not clear on which bases they affect neuroprotection and the mechanism responsible is yet unknown.

In this study, we have characterized in nerve growth factor‐differentiated pheochromocytoma PC12 cells injured with hypoxia: (i) the effects of PEMF exposure on cell vitality; (ii) the protective pathways activated by PEMFs to relief neuronal cell death, including adenylyl cyclase, phospholipase C, protein kinase C epsilon and delta, p38, ERK1/2, JNK1/2 mitogen‐activated protein kinases, Akt and caspase‐3; (iii) the regulation by PEMFs of prosurvival heat‐shock proteins of 70 (HSP70), cAMP response element‐binding protein (CREB), brain‐derived neurotrophic factor (BDNF), and Bcl‐2 family proteins. The results obtained in this study show a protective effect of PEMFs that are able to reduce neuronal cell death induced by hypoxia by modulating p38, HSP70, CREB, BDNF, and Bcl‐2 family proteins. Specifically, we found a rapid activation (30 min) of p38 kinase cascade, which in turns enrolles HSP70 survival chaperone molecule, resulting in a significant CREB phosphorylation increase (24 hr). In this cascade, later (48 hr), BDNF and the antiapoptotic signaling pathway regulated by the Bcl‐2 family of proteins are recruited by PEMFs to enhance neuronal survival.

This study paves the way to elucidate the mechanisms triggered by PEMFs to act as a new neuroprotective approach to treat cerebral ischemia by reducing neuronal cell death.

Stefania Gessi, Stefania Merighi, Serena Bencivenni, Enrica Battistello, Fabrizio Vincenzi, Stefania Setti, Matteo Cadossi, Pier Andrea Borea, Ruggero Cadossi, Katia Varani. Journal of Cellular Physiology, January 17, 2019, https://doi.org/10.1002/jcp.28149.

Source

Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation

September 22, 2022

PEMF Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells

Pulsed electromagnetic fields (PEMFs) have been documented to promote bone fracture healing in nonunions and increase lumbar spinal fusion rates. However, the molecular mechanisms by which PEMF stimulates differentiation of human bone marrow stromal cells (hBMSCs) into osteoblasts are not well understood. In this study the PEMF effects on hBMSCs were studied by microarray analysis. PEMF stimulation of hBMSCs’ cell numbers mainly affected genes of cell cycle regulation, cell structure, and growth receptors or kinase pathways. In the differentiation and mineralization stages, PEMF regulated preosteoblast gene expression and notably, the transforming growth factor-beta (TGF-β) signaling pathway and microRNA 21 (miR21) were most highly regulated. PEMF stimulated activation of Smad2 and miR21-5p expression in differentiated osteoblasts, and TGF-β signaling was essential for PEMF stimulation of alkaline phosphatase mRNA expression. Smad7, an antagonist of the TGF-β signaling pathway, was found to be miR21-5p’s putative target gene and PEMF caused a decrease in Smad7 expression. Expression of Runx2 was increased by PEMF treatment and the miR21-5p inhibitor prevented the PEMF stimulation of Runx2 expression in differentiating cells. Thus, PEMF could mediate its effects on bone metabolism by activation of the TGF-β signaling pathway and stimulation of expression of miR21-5p in hBMSCs.

Selvamurugan, N., He, Z., Rifkin, D., Dabovic, B., & Partridge, N. C. (2017). Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation. Stem cells international, 2017, 2450327. https://doi.org/10.1155/2017/2450327

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Pulsed electromagnetic field therapy effectiveness in low back pain: A systematic review of randomized controlled trials

September 22, 2022

Pulsed electromagnetic field therapy effectiveness in low back pain: A systematic review of randomized controlled trials

Low back pain is a worldwide prevalent musculoskeletal condition in the general population. In this sense, the pulsed electromagnetic fields (PEMF) therapy has shown significant clinical benefits in several musculoskeletal conditions. This study was conducted to assess the effectiveness of the PEMF therapy in reducing pain and clinical symptomatology in patients with low back pathological conditions. It was performed a comprehensive database search using Pubmed, Scopus, Cochrane Library and PEDro databases to assess the effectiveness of the PEMF therapy in reducing pain and clinical symptomatology in patients with low back pathological conditions. The search was performed from January 2005 to August 2015 and conducted by two independent investigators, which scrutinize the reference list of most relevant studies. The methodological quality was assessed by the PEDro scale and the level of evidence was set according Oxford Center for Evidence-Based Medicine scale. Six studies were eligible inclusion on the qualitative analysis and five into the quantitative analysis, scoring an overall 6.8 points according the PEDro scale. The studies showed heterogeneity concerning the intervention protocols. Nevertheless, the effect sizes’ indicated a clear tendency to reduction of the pain intensity favoring the PEMF groups, reaching a minimal clinically important difference. Conclusion. PEMF therapy seems to be able to relieve the pain intensity and improve functionality in individuals with low back pain conditions. Further research is needed regarding PEMF effects on the different conditions of low back pain, with standardized protocols, larger samples and adjustment for low back pain confounders in order to achieve stronger conclusions. Renato Andrade, Hugo Duarte, Rogério Pereira, Isabel Lopes, Hélder Pereira, Rui Rocha, João Espregueira-Mendes, Pulsed electromagnetic field therapy effectiveness in low back pain: A systematic review of randomized controlled trials, Porto Biomedical Journal, Volume 1, Issue 5, 2016, Pages 156-163, ISSN 2444-8664, https://doi.org/10.1016/j.pbj.2016.09.001. Source

Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage

September 22, 2022

Repetitive HBOT increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage

The role of hyperbaric oxygen therapy (HBOT) in the treatment of acute ischemic stroke is controversial. This study aims to investigate whether the peripheral insulin sensitivity of type 2 diabetes patients suffering from intracerebral hemorrhage can be increased after HBOT. Fifty-two type 2 diabetes participants were recruited after being diagnosed with intracerebral hemorrhage in our hospital. Insulin sensitivity was measured by the glucose infusion rate during a hyperinsulinemic euglycemic clamp (80 mU m-2 min-1) at baseline and 10 and 30 days after HBOT sessions. Serum insulin, fasting glucose, and hemoglobin A1C were measured in fasting serum at baseline and after HBOT sessions. In addition, early (∼10 days after onset) and late (1 month after onset) outcomes (National Institutes of Health Stroke Scale, NIHSS scores) and efficacy (changes of NIHSS scores) of HBOT were evaluated. In response to HBOT, the glucose infusion rate was increased by 37.8%±5.76% at 1 month after onset compared with baseline. Reduced serum insulin, fasting glucose, and hemoglobin A1C were observed after HBOT. Both early and late outcomes of the HBOT group were improved compared with baseline (P<0.001). In the control group, there was significant difference only in the late outcome (P<0.05). In the assessment of efficacy, there were statistically significant differences between the groups when comparing changes in NIHSS scores at 10 days and 1 month after onset (P<0.05). Conclusion. Peripheral insulin sensitivity was increased following HBOT in type 2 diabetes patients with intracerebral hemorrhage. The HBOT used in this study may be effective for diabetes patients with acute stroke and is a safe and harmless adjunctive treatment. Xu Q, Wei YT, Fan SB, Wang L, Zhou XP. Repetitive hyperbaric oxygen treatment increases insulin sensitivity in diabetes patients with acute intracerebral hemorrhage. Neuropsychiatr Dis Treat. 2017 Feb 10;13:421-426. doi: 10.2147/NDT.S126288. PMID: 28228657; PMCID: PMC5312693.

REVERSE THE SIGNS OF AGING SKIN THROUGH HYPERBARIC OXYGEN THERAPY

September 14, 2022

REVERSE THE SIGNS OF AGING SKIN THROUGH HYPERBARIC OXYGEN THERAPY

A landmark study published in "Aging" clearly demonstrates the benefits of hyperbaric oxygen therapy(HBOT) for skin health and structural integrity for older individuals. More specifically, the application of a 3 month hyperbaric protocol showed "significant aging modulation effects by decreasing senescent cells, inducing angiogenesis and increasing elastic fiber length and stability and collagen density.

It should be noted that skin aging is largely influenced by a lack of circulation and higher cell senescence, both of which can be counteracted with a simple course of hyperbaric oxygen therapy.

The hyperbaric protocol comprised of 60 daily sessions, five sessions per week within a three-month period. Each session included breathing 100% oxygen by mask at 2ATA for 90 minutes with five-minute air breaks every 20 minutes.

Researchers used a combination of skin biopsies and other dermatological markers to document these results on a total of 13 elderly individuals (averaging 68 years of age). <view study>

The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial | Aging (aging-us.com)

**Please note we offer 1.3ATA which is proven to be just as beneficial as 2.0ATA <view study The Debate is over — Low pressure hyperbaric oxygen therapy proves its effectiveness – @Hyperbaric Experts>

The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings

September 22, 2022

The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings

Bone fractures are one of the most commonly occurring injuries of the musculoskeletal system. A highly complex physiological process, fracture healing has been studied extensively. Data from in vivo, in vitro and clinical studies, have shown pulsed electromagnetic fields (PEMFs) to be highly influential in the fracture repair process. Whilst the underlying mechanisms acting to either inhibit or advance the physiological processes are yet to be defined conclusively, several non-invasive point of use devices have been developed for the clinical treatment of fractures. With the complexity of the repair process, involving many components acting at different time steps, it has been a challenge to determine which PEMF exposure parameters (i.e., frequency of field, intensity of field and dose) will produce the most optimal repair. In addition, the development of an evidence-backed device comes with challenges of its own, with many elements (including process of exposure, construct materials and tissue densities) being highly influential to the field exposed. The objective of this review is to provide a broad recount of the applications of PEMFs in bone fracture repair and to then demonstrate what is further required for enhanced therapeutic outcomes. Daish, Christian & Blanchard, Romane & Fox, Kate & Pivonka, Peter & Pirogova, Elena. (2018). The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. Annals of Biomedical Engineering. 46. 10.1007/s10439-018-1982-1. Source

The impact of pulsed electromagnetic field therapy on blood pressure and circulating nitric oxide levels: a double-blind, randomized study in subjects with metabolic syndrome

September 22, 2022

The impact of pemf therapy on blood pressure and circulating nitric oxide levels: a double blind, randomized study

Regulation of blood pressure (BP) is important in reducing the risk for cardiovascular disease. There is growing interest in non-pharmacological methods to treat BP including a novel approach using pulsed electromagnetic field therapy (PEMF). PEMF therapy has been proposed to impact physiological function at the cellular and tissue level and one possible mechanism is through an impact on endothelial function and nitric oxide (NO) related pathways. The focus of the present study was to evaluate the effect of PEMF on BP and NO in subjects with mild to moderate metabolic syndrome. For 12 weeks, 23 subjects underwent PEMF therapy and 21 subjects underwent sham therapy. BP was measured at rest and near the end of submaximal exercise pre- and 12 week post-therapy. Additionally, plasma NO was measured at similar time points.

Conclusion. PEMF may increase plasma NO availability and improve BP at rest and during exercise. However, this beneficial effect appears to be more pronounced in subjects with existing hypertension.

Chul-Ho Kim, Courtney M. Wheatley-Guy, Glenn M. Stewart, Dongwook Yeo, Win-Kuang Shen & Bruce D. Johnson (2020) The impact of pulsed electromagnetic field therapy on blood pressure and circulating nitric oxide levels: a double blind, randomized study in subjects with metabolic syndrome, Blood Pressure, 29:1, 47-54, DOI: 10.1080/08037051.2019.1649591

Source

The use of magnetic devices in treating sexual disorders in men

September 22, 2022

The use of magnetic devices in treating sexual disorders in men

An effect was studied of appliances for magnetotherapy on sexual function of 105 men presenting with sexual problems. A total of 96 sexological patients were examined according to a general programme, to study placebo-effect. The magnetic field beneficial effect was recordable in 70-80 % of the patients, that of placebo in 33 % men. It is suggested that augmentation of sexual activity is associated with an increase in cavernous bloodflow. Gorpinchenko II. Ispol ‘zovanie magnitnykh apparatov v lechenii seksual’nykh rasstroĭstv u muzhehin [The use of magnetic devices in treating sexual disorders in men]. Lik Sprava. 1995 Mar-Apr;(3-4):95-7. Russian. PMID: 8819933. Source

Transcranial Low Voltage Pulsed Electromagnetic Fields in Patients with Treatment-Resistant Depression

September 22, 2022

Transcranial Low Voltage Pulsed Electromagnetic Fields in Patients with Treatment-Resistant Depression

Approximately 30% of patients with depression are resistant to antidepressant drugs. Repetitive transcranial magnetic stimulation (rTMS) has been found effective in combination with antidepressants in this patient group. The aim of this study was to evaluate the antidepressant effect of a new principle using low-intensity transcranially applied pulsed electromagnetic fields (T-PEMFs) in combination with antidepressants in patients with treatment-resistant depression.

This was a sham-controlled double-blind study comparing 5 weeks of active or sham T-PEMFs in patients with treatment-resistant major depression. The antidepressant treatment, to which patients had been resistant, was unchanged 4 weeks before and during the study period. Weekly assessments were performed using both clinician-rated and patient-rated scales. The T-PEMF equipment was designed as a helmet containing seven separate coils located over the skull that generated an electrical field in tissue with orders of magnitude weaker than those generated by rTMS equipment

Patients on active T-PEMFs showed a clinically and statistically significant better outcome than patients treated with sham T-PEMFs, with an onset of action within the first weeks of therapy. Effect size on the Hamilton 17-item Depression Rating Scale was .62 (95% confidence interval .21–1.02). Treatment-emergent side effects were few and mild.

Conclusion. The T-PEMF treatment was superior to sham treatment in patients with treatment-resistant depression. Few side effects were observed. Mechanism of the antidepressant action, in light of the known effects of PEMF stimulation to the brain, is discussed.

Klaus Martiny, Marianne Lunde, Per Bech, Transcranial Low Voltage Pulsed Electromagnetic Fields in Patients with Treatment-Resistant Depression, Biological Psychiatry, Volume 68, Issue 2, 2010, Pages 163-169, ISSN 0006-3223,
https://doi.org/10.1016/j.biopsych.2010.02.017.

Source

Transcranial low-frequency pulsating electromagnetic fields (T-PEMF) as post-concussion syndrome treatment

September 21, 2022

Transcranial low-frequency pulsating electromagnetic fields (T-PEMF) as post-concussion syndrome treatment

A small but significant number of mild traumatic brain injuries (mTBI) result in development of persistent prolonged symptoms, including cognitive deficits, headaches, and mental fatigue. Such symptoms are called post-concussion syndrome (PCS), usually diagnosed according to the International Classification of Disease (ICD)-10 or the Diagnostic and Statistical Manual of Mental Disorder (DSM)-IV. However, the concept of PCS as one unique syndrome is debated, and it remains unclear clear why and who develops PCS. The majority of studies use the term PCS to describe persistent concussion symptoms over 3 months following a non-penetrating direct or indirect blow to the head accompanied by loss of consciousness or alterations in mental state for <30 minutes. Current management of PCS consists of a multidisciplinary approach of pharmaceutical treatment, vestibular and vision rehabilitation, cognitive behavioral therapy and physical therapy. A meta-analysis from 2018 of PCS intervention, however, found evidence of concussion treatment limited. Treatment with low-frequency pulsating electromagnetic fields (PEMF) is a non-invasive, self-administered method best known from treatment of non-union long bone fractures where accelerated bone healing process has been well-established. Low-frequency electromagnetic field therapy has since evolved to include transcranial application based on in vitro and experimental in vivo findings of neuroprotective effects including cell proliferation and differentiation, enhanced neurite outgrowth, reduced apoptosis, increased angiogenesis, and increased microvascular perfusion and tissue oxygenation. Compliance was high as all subject completed the full treatment. Two patients however experienced a worsening of their concussion symptoms during the course of treatment. The remaining patients had some discomfort in relation to treatment, mainly headache, but passing and less for each treatment. The majority (n = 5) had a reduction in symptoms overall, up to 61% (2%-61%) based on the Rivermead Post-Concussion Symptoms Questionnaire. Further studies on T-PEMF as a treatment option for post-concussion syndrome are warranted. Miller CP, Prener M, Dissing S, Paulson OB. Transcranial low-frequency pulsating electromagnetic fields (T-PEMF) as post-concussion syndrome treatment. Acta Neurol Scand. 2020;142:597–604. https://doi.org/10.1111/ane.13300 Source

Treatment of depression with low-strength transcranial pulsed electromagnetic fields: A mechanistic point of view

September 22, 2022

Treatment of depression with low-strength transcranial pulsed electromagnetic fields: A mechanistic point of view

Mood disorders constitute a high burden for both patients and society. Notwithstanding the large arsenal of available treatment options, a considerable group of patients does not remit on current antidepressant treatment. There is an urgent need to develop alternative treatment strategies. Recently, low-strength transcranial pulsed electromagnetic field (tPEMFs) stimulation has been purported as a promising strategy for such treatment-resistant depression (TRD). The mode of action of this new technique is however largely unknown.

Most studies more or less connect with the major hypotheses of depression and concern the effects of tPEMFs on brain metabolism, neuronal connectivity, brain plasticity, and the immune system. Relatively few studies paid attention to the possible chronobiologic effects of electromagnetic fields.

Conclusion. Weak magnetic fields influence divergent neurobiological processes. The antidepressant effect of tPEMFs may be specifically attributable to its effects on local brain activity and connectivity.

Keywords: Biological clock; Circadian rhythms; Cryptochrome; Depression; MDD; PEMFs; TMS; Weak electromagnetic fields; tPEMFs.

van Belkum SM, Bosker FJ, Kortekaas R, Beersma DG, Schoevers RA. Treatment of depression with low-strength transcranial pulsed electromagnetic fields: A mechanistic point of view. Prog Neuropsychopharmacol Biol Psychiatry. 2016 Nov 3;71:137-43. doi: 10.1016/j.pnpbp.2016.07.006. Epub 2016 Jul 21. PMID: 27449361.

Source

Use of a PEMF to Treat Complex TBI with Brain Gauge and Rivermead Outcome Measures

September 22, 2022

Use of a PEMF to Treat Complex TBI with Brain Gauge and Rivermead Outcome Measures

The US Centers for Disease Control (CDC) claims that about 2.5 million cases of death, hospital admissions and emergency visits occurred in 2010 for traumatic brain injury (TBI), but this is expected to be a significant underestimate. It is also estimated that about 5.3 million Americans are living with post TBI disabilities. Certain populations are at higher risk for TBI with brain Gauge and Rivermead Outcome. For sports,  between 1.6 and 3.8 million sports – related concussions are estimated to occur annually within the USA1. The military population is another major at-risk group, with screening indicating a prevalence rate of about 6.8%.

TBI should not be considered as an acute event but as a trigger of progressive injury which may occur over hours, days, weeks, months and even years3. TBI is not only a progressive disease in the early phase, but, may also, evolve into a chronic disease. The development and implementation of guidelines for many aspects of the care of TBI have led to uncritical adoption of a “one-size-fits-all,” standardized approach. This approach largely considers people with TBI to be “average patients.” Because of the complexity of TBI and the uniqueness of individuals sustaining these injuries, care needs to be individualized.

In most cases of mild traumatic brain injury (mTBI), also called concussion, the symptoms disappear in the first 2 to 4 weeks4. Symptoms that persist for months or years following the injury are considered persistent post-concussion syndrome (PCS). PCS symptoms include somatic symptoms (i.e., headache, blurry vision, anxiety, etc.) and cognitive (i.e., confusion, memory) deficits. In 20–40% of mTBI cases symptoms can still be present at 6 months post-injury, and in 10–20% of cases they may still be symptomatic at 1 year and beyond.

This case report and discussion provide substantial support for the use of this specific 10 mT/100 Gauss pulsed magnetic field 10 Hz signal for 2 hours daily to not only significantly improve clinical function, but also to objectively produce positive neurological functional changes. Further research is clearly needed on a larger sample of individuals with TBI, whether complex or not, with different times after onset of injury. It is still unknown whether 2 hours per day of this type of PEMF therapy is optimal. Clearly, in this patient, 2 hours/day of therapy made significant improvements in subjective and objective measures of function, and with internal validity, significant loss of benefit with cessation of therapy. This loss of benefit with stopping treatment has been seen in other transcranial PEMF research. It remains to be seen whether durable, long-term benefits can be seen with longer-term PEMF therapy, whether other signal parameters could be optimized, including PEMF frequencies and intensities, and whether more permanent structural improvements in the injured brain may be found.

William Pawluck, PEMF Training Academy, Journal of Science and Medicine, Vol 2, No. 1 (2020), DOI: 10.37714/JOSAM.V1|2.32

Source

What we know about PEMF Therapy and Peak Performance

September 22, 2022

What we know about PEMF Therapy and Peak Performance

There is a general notion that PEMF therapy increases energy and may renew energy. This has been a constant theme among researchers and those who have given this revolutionary therapy a try for chronic conditions that may cause fatigue. Chronic conditions get a lot of attention, but it can give a healthy boost of energy to knpw anyone who struggles with fatigue. Athletes have been seeking PEMF devices to aid in enhancing their Peak performance. This is true for a few reasons:

  • PEMF therapy is beneficial for renewing energy (as we learned above).
  • PEMF therapy is beneficial for improving the condition of the muscles and joints.
  • PEMF therapy is beneficial for improving the condition of tissues and blood flow.
  • PEMF therapy has been highly regarded as a natural method of improving mental clarity.

Read More

PEMF Therapy Education, March 7, 2018.