What we know about PEMF Therapy and Peak Performance There is a general notion that PEMF therapy increases energy and may renew energy. This has been a constant theme among researchers and those who have given this revolutionary therapy a try for chronic conditions that may cause fatigue. Chronic conditions get a lot of attention, but it can give a healthy boost of energy to knpw anyone who struggles with fatigue. Athletes have been seeking PEMF devices to aid in enhancing their Peak performance. This is true for a few reasons: PEMF therapy is beneficial for renewing energy (as we learned above). PEMF therapy is beneficial for improving the condition of the muscles and joints. PEMF therapy is beneficial for improving the condition of tissues and blood flow. PEMF therapy has been highly regarded as a natural method of improving mental clarity. Read More PEMF Therapy Education, March 7, 2018.
Mechanisms and therapeutic applications of electromagnetic therapy in Parkinson’s disease Electromagnetic therapy is a non-invasive and safe approach for the management of several pathological conditions including neurodegenerative diseases. Parkinson’s disease is a neurodegenerative pathology caused by abnormal degeneration of dopaminergic neurons in the ventral tegmental area and substantia nigra pars compacta in the midbrain resulting in damage to the basal ganglia. Electromagnetic therapy has been extensively used in the clinical setting in the form of transcranial magnetic stimulation, repetitive transcranial magnetic stimulation, high-frequency transcranial magnetic stimulation and pulsed electromagnetic field therapy which can also be used in the domestic setting. In this review, we discuss the mechanisms and therapeutic applications of electromagnetic therapy to alleviate motor and non-motor deficits that characterize Parkinson’s disease. Vadalà, M., Vallelunga, A., Palmieri, L. et al. Mechanisms and therapeutic applications of electromagnetic therapy in Parkinson’s disease. Behav Brain Funct 11, 26 (2015). https://doi.org/10.1186/s12993-015-0070-z Source
Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients exposed to microvascular endothelial cells conditioned medium
Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients Intervertebral disc (IVD) degeneration with chronic low back pain is associated with neo-vascularisation into the deeper IVD regions. During this process, endothelial cells (ECs), which are primarily responsible for angiogenesis, interact with the adjacent annulus fibrosus (AF) cells, which are the first line of defence against the invasion of vascular structures into deeper IVD regions. However, the accumulation of inflammatory and catabolic enzymes that results from this interaction promotes matrix degradation and an inflammatory response. Thus, regulating the production of these mediators and catabolic enzymes could ameliorate IVD degeneration. Photobiomodulation (PBM) therapy is a non-invasive stimulation known to have biologically beneficial effects on wound healing, tissue repair, and inflammation. Here, we examined the effects of PBM, administered at various wavelengths (645, 525, and 465 nm) and doses (16, 32, and 64 J/cm2), on EC-stimulated human AF cells. Our results show that PBM selectively inhibited the EC-mediated production of inflammatory mediators, catabolic enzymes, and neurotrophins by human AF cells in a dose- and wavelength-dependent manner. These results suggest that PBM could be a superior and advanced treatment strategy for IVD degeneration. Hwang MH, Lee JW, Son HG, Kim J, Choi H. Effects of photobiomodulation on annulus fibrosus cells derived from degenerative disc disease patients exposed to microvascular endothelial cells conditioned medium. Sci Rep. 2020 Jun 15;10(1):9655. doi: 10.1038/s41598-020-66689-0. PMID: 32541845; PMCID: PMC7296027. Source
Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation
PEMF Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells Pulsed electromagnetic fields (PEMFs) have been documented to promote bone fracture healing in nonunions and increase lumbar spinal fusion rates. However, the molecular mechanisms by which PEMF stimulates differentiation of human bone marrow stromal cells (hBMSCs) into osteoblasts are not well understood. In this study the PEMF effects on hBMSCs were studied by microarray analysis. PEMF stimulation of hBMSCs’ cell numbers mainly affected genes of cell cycle regulation, cell structure, and growth receptors or kinase pathways. In the differentiation and mineralization stages, PEMF regulated preosteoblast gene expression and notably, the transforming growth factor-beta (TGF-β) signaling pathway and microRNA 21 (miR21) were most highly regulated. PEMF stimulated activation of Smad2 and miR21-5p expression in differentiated osteoblasts, and TGF-β signaling was essential for PEMF stimulation of alkaline phosphatase mRNA expression. Smad7, an antagonist of the TGF-β signaling pathway, was found to be miR21-5p’s putative target gene and PEMF caused a decrease in Smad7 expression. Expression of Runx2 was increased by PEMF treatment and the miR21-5p inhibitor prevented the PEMF stimulation of Runx2 expression in differentiating cells. Thus, PEMF could mediate its effects on bone metabolism by activation of the TGF-β signaling pathway and stimulation of expression of miR21-5p in hBMSCs. Selvamurugan, N., He, Z., Rifkin, D., Dabovic, B., & Partridge, N. C. (2017). Pulsed Electromagnetic Field Regulates MicroRNA 21 Expression to Activate TGF-β Signaling in Human Bone Marrow Stromal Cells to Enhance Osteoblast Differentiation. Stem cells international, 2017, 2450327. https://doi.org/10.1155/2017/2450327 Source
The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings
The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings Bone fractures are one of the most commonly occurring injuries of the musculoskeletal system. A highly complex physiological process, fracture healing has been studied extensively. Data from in vivo, in vitro and clinical studies, have shown pulsed electromagnetic fields (PEMFs) to be highly influential in the fracture repair process. Whilst the underlying mechanisms acting to either inhibit or advance the physiological processes are yet to be defined conclusively, several non-invasive point of use devices have been developed for the clinical treatment of fractures. With the complexity of the repair process, involving many components acting at different time steps, it has been a challenge to determine which PEMF exposure parameters (i.e., frequency of field, intensity of field and dose) will produce the most optimal repair. In addition, the development of an evidence-backed device comes with challenges of its own, with many elements (including process of exposure, construct materials and tissue densities) being highly influential to the field exposed. The objective of this review is to provide a broad recount of the applications of PEMFs in bone fracture repair and to then demonstrate what is further required for enhanced therapeutic outcomes. Daish, Christian & Blanchard, Romane & Fox, Kate & Pivonka, Peter & Pirogova, Elena. (2018). The Application of Pulsed Electromagnetic Fields (PEMFs) for Bone Fracture Repair: Past and Perspective Findings. Annals of Biomedical Engineering. 46. 10.1007/s10439-018-1982-1. Source
Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders Increasing evidence suggests that an exogenous electromagnetic field might be involved in many biologic processes which are of great importance for therapeutic interventions. Pulsed electromagnetic fields (PEMFs) are known to be a noninvasive, safe and effective therapy agent without apparent side effects. Numerous studies have shown that PEMFs possess the potential to become a stand-alone or adjunctive treatment modality for treating musculoskeletal disorders. However, several issues remain unresolved. Prior to their widely clinical application, further researches from well-designed, high-quality studies are still required to standardize the treatment parameters and derive the optimal protocol for health-care decision making. In this review, we aim to provide current evidence on the mechanism of action, clinical applications, and controversies of PEMFs in musculoskeletal disorders. Highlights are that pulsed electromagnetic fields (PEMFs) are a noninvasive, safe and effective physical therapy, with no significant side effects and that PEMFs provide a new alternative for the treatment of various musculoskeletal disorders. Further study is warranted to confirm the benefits of PEMF therapy on a variety of musculoskeletal disorders. Hongzhi Hu, Wenbo Yang, Qianwen Zeng, Wei Chen, YanBin Zhu, Weijian Liu, Shangyu Wang, Baichuan Wang, Zengwu Shao, Yingze Zhang, Promising application of Pulsed Electromagnetic Fields (PEMFs) in musculoskeletal disorders, Biomedicine & Pharmacotherapy, Volume 131, 2020, 110767, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2020.110767. Source
How PEMF therapy repairs the damage from Lyme Disease Did you know that the damage from Lyme Disease can have a long-term impact on your health? Lyme Disease can cause short-term damage and repairs long-term damage as it settles into the tissues and organs. The goal is to knock out the infection before it spreads into the tissues and organs, but the infection is not always treated immediately. Oftentimes, someone that has been bit by a tick may not feel it, or they never see a bull’s eye shaped bite on their leg. As the infection grows and settles into the organs and tissues, inflammation and scarring occur, causing damage to those tissues and organs. Antibiotics are always the first course of action, and when those are not given early on the infection continues to grow. PEMF therapy is a viable adjunctive option, and it can be just as powerful as the antibiotics, as well as when used in conjunction with antibiotics. PEMF therapy has been highly regarded as a safe and non-invasive way to reduce symptoms for numerous diseases and conditions, including damage from Lyme Disease. As electromagnetic waves move down to the cellular level, they can reduce inflammation, improve circulation, and reduce pain. PEMF therapy is a powerful complementary therapy, and this therapy may increase the effectiveness of conventional therapies. PEMF Therapy Education, May 25, 2017. Source
Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats
Effects of PEMF on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats Levels of antioxidants in individuals with diabetes increase initially as a response to increases in reactive oxygen species (ROS) and later decrease due to reactions between free radicals and antioxidants. As the disease progresses, antioxidant mechanisms can be damaged in parallel to tissue damage, reducing antioxidant levels. Generalization should be avoided, however, due to increases in vitamin E levels due to hyperlipidemia and increases in ferritin levels due to of inflammation. The effects of antioxidants in organs are dependent on tissue physiology. Enzymatic antioxidants are more effective within cells, whereas non-enzymatic antioxidants have a greater effect in the extracellular environment. In conclusion, this study investigated the antioxidant effects of PEMF in a rat model of diabetes. PEMF altered the levels of MDA, NO, MPO, SOD, and GSH, suggesting that it regulates diabetes-associated damage. PEMF exerts these effects by reducing oxidative stress and increasing antioxidant levels. These findings suggest that PEMF may become a widespread non-invasive treatment option for diabetes and its complications. Gözen H, Demirel C, Akan M, Tarakçıoğlu M. Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats. Eur J Ther 2017; 23: 152-8. Source
Effect of Electromagnetic Field and Allicin as Natural Extract on Hepatocellular Carcinoma (HepG2) Cancer is one of the major public burdens worldwide. It is a multicellular disease that can arise from all cell type. In the recent decades, the number of cancer related showed a clear elevation, in turn creating huge health and economic problems. Non-ionizing Electromagnetic Fields (EMF), from extremely-low frequency to radiofrequency, have been shown to cause biological effects even at low intensity. Some of these effects may be applied for medical treatments. Exposure to PEMFs in the 0-300Hz range is a therapeutic tool extensively used for the treatment of several pathologies. Allicin is an organic sulfur compound from the bulbs of Allium sativum, which is also present in onions and other Allianceae plants. Allicin has strong antibacterial and anti-inflammatory effects, and may inhibit the growth of or kill various bacteria, fungi and viruses. A previous epidemiological study demonstrated the antitumor activity of allicin has been shown to directly kill tumor cells, inhibit tumor cell proliferation and induce apoptosis. Aim of Study: This study investigates the anticancer activity of EMF, allicin and combination between them in the treatment of Hepatocellular carcinoma (HepG2). Material and Methods: Human Hepatocellular carcinoma (HepG2) ATCC®HB-8065 cell lines was supplied from Re-search and Development Sector, The Holding Company for production of Vaccines, Sera and Drugs (VACSERA), Cairo, Egypt. Electromagnetic fields exposure, Allicin 95% was kindly supplied from the national organization for drug control and research (NODCAR). Cytotoxicity, Flowcytometry and Quantitative Real-Time RT PCR (q RT-PCR) anticancer activity of EMF, EMF-Allicin and Allicin compared to cisplatin was investigated through the expression of BAX, P53 and BCL2 genes using real-time RT-PCR. Results: Data revealed that cytotoxicity was concentration and cell type-dependent, as lower concentration enhanced the higher viability profile, the concentration of allicin of 2µg/ml, cell viability reached 100% on both of vero cells and HepG2 cells. The inhibitory concentration (IC50) for Vero cells, and HepG2 was 9.47µg/ml and 69.4µg/m respectively. The treatment with both EMF-Allicin is more efficient than treatment with EMF or Allicin separately. In the present study there was a significant up regulation of both pro-apoptotic genes (Bax- P53) accompanied by significant down regulation of anti-apoptotic gene (BCL-2) relative to exposure to EMF + Allicin. Conclusion: EMF can be used in therapy as its non-invasive technique used for the treatment of several pathologies and cancer. Combination between EMF + Allicin can induce apoptosis and inhibition of proliferation in HepG2 cell line. Ph.D., MAHA & AZIZ, M.Sc. (2020). Effect of Electromagnetic Field and Allicin as Natural Extract on Hepatocellular Carcinoma (HepG2). The Medical Journal of Cairo University. 88. 815-825. 10.21608/mjcu.2020.104890. Source
PEMF Therapy for Pain Relief When it comes to managing chronic pain, PEMF therapy for pain relief is a powerful tool. Are you new to the world of PEMF therapy? If so, you may have some questions about what it is, how it works, or what a session is like. Let’s look at some of the frequently asked questions regarding PEMF therapy in regards to pain. Join us, and learn more about how this treatment can help you. PEMF is an acronym for Pulsed Electro-Magnetic Field. PEMF therapy consists of a device which emits pulses of energy waves. This energy courses through the body, directly to damaged or injured areas. The energy is particularly drawn to areas experiencing chronic pain and inflammation. The energy of the PEMF device passes through the cells in your body, amplifying the cellular energy. The increase in energy promotes a natural reaction that regenerates and enhances the efficiency of the cell’s function. This natural process stimulates healing and helps to improve your overall well-being. There are different types of PEMF therapy devices. The type of device best suited for you will depend on your needs and preferred method of application. PEMF mats rest on a table, floor or bed. The mats allow the user to lay directly on the PEMF device and have electromagnetic pulses course throughout the entire body. These devices are a popular option for folks suffering from chronic pain and inflammation. The full body mat energizes all of the cells in your body/ Other accessory PEMF devices provide more direct pulses of energy for localized pain. For example, if you are having difficulties with pain in your knee joint, a PEMF ring is a beneficial option for delivery of pulses directly to the joint. The application process is simple and easy. There is no need for special preparation or chemical numbing agents. Simply order a PEMF device that is appropriate for your needs. As soon as your product arrives, you may start using it in the comfort and privacy of your home. In most cases, PEMF therapy does not cause side effects. It’s a safe therapy that most people use with little to no negative effects. Physicians do not recommend PEMF therapy for people with pacemakers or other electrical implants. Studies show that, in rare cases, certain types of PEMF devices can interfere with the electronics in pacemakers. Because of this, we recommend consulting with your doctor before using a PEMF device if you have a pacemaker. Most of the problems with pacemakers occur with the use of high intensity PEMF devices which are not common for in home use. Hopefully, this has helped you learn more about PEMF therapy and how it offers relief from conditions like fibromyalgia, muscle pain, arthritis, and musculoskeletal pain. PEMF therapy is a great option for natural, chemical free pain relief and overall wellness. Read more PEMF Therapy Education, Apr 29, 2019.